Cardio-IHD Flashcards

1
Q

Cornerstone in the diagnosis of acute and chronic ischemic heart disease

A

Electrocardiogram(ECG)

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2
Q

Most common underlying cause of myocardial ischemia and injury

A

Obstruction of coronary arteries by atherosclerosis

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3
Q

Infection associated with accelerated atherosclerosis

A

Chlamydophila pneumoniae

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4
Q

Most common cause of anterior chest musculoskeletal pain

A

Costochondral and chondrosternal syndromes

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5
Q

Myocardial perfusion occurs during this time

A

Diastole

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6
Q

Represents initial lesion of atherosclerosis

A

Fatty streak

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7
Q

Major features of metabolic syndrome

A
Central obesity
Hyperglycemia
Hypertriglyceridemia
Hypertension
Low HDL cholesterol
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8
Q

Age when lipid screening should start(based on current ATP III guidelines)

A

All adults >25 years(fasting lipid profile)

Repeated every 5 years

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9
Q

Key feature in metabolic syndrome

A

Central adiposity

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10
Q

Most accepted unifying hypothesis to describe pathophysiology of metabolic syndrome

A

Insulin resistance

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11
Q

Driving force behind the metabolic syndrome

A

Obesity

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12
Q

Most common cause of myocardial ischemia

A

Atherosclerotic disease of epicardial coronary artery

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13
Q

Most common vessel involved in MI

A

Left anterior descending artery

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14
Q

Sites of predilection for atherosclerotic plaques to develop due to increased turbulence

A

Branch points in the epicardial arteries

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15
Q

Time frame for reversible damage in myocardium

A

<20 minutes for total occlusion in the absence of collaterals

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16
Q

Most widely used test for both the diagnosis of IHD and estimating the prognosis

A

Electrocardiographic stress testing

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17
Q

Common pathophysiologic cause of unstable angina

A

Plaque rupture or erosion with super imposed non occlusivethrombus

18
Q

Only absolute contraindication to nitrate use

A

Hypotension

Sildenafil(or similar drug) in previous 24hr

19
Q

Most common artery involved in Prinzmetal angina

A

Right coronary artery

20
Q

Main agents for acute episodes and to abolish recurrent episodes of Prinzmetal’s angina

A

Nitrates and calcium channel blockers(Nifedipine)

21
Q

Types of necrosis seen in MI

A

Coagulation necrosis(preserved architecture, faded details)

22
Q

Earliest detectable feature of myocyte necrosis

A

Sarcolemmal membrane disruption(which leads to leakage of cardiac enzymes into the circulation)

23
Q

Time frame where gross changes in MI occur

A

12 hours after onset of symptoms

24
Q

Color changes in MI

A

Mottling- 4 hrs
Bright yellow- 1 wk
Surrounding red granulation tissue- 2 wks
Gray-white scar- 2 months

25
Fibrinous pericarditis (bread and butter pericarditis) post-MI
Dressler syndrome
26
Sites of myorcadial rupture in MI
Free wall > IVS > Papillary muscle (decreasing order of frequency)
27
Preferred biochemical markers for MI
Cardiac-specific Troponin T and Troponin I
28
Preferred biochemical markers for re-infarction
CK-MB
29
Level of coronary artery stenosis sufficient to produce ischemia
70%(critical stenosis)
30
Primary cause of out-of-hospital deaths from STEMI
Ventricular fibrillation
31
Primary cause of in-of-hospital deaths from STEMI
Pump failure
32
Greatest delay usually occurs between
Onset of pain & patient’s decision to call for help
33
Principal goal of fibrinolysis
Prompt restoration of full coronary arterial patency
34
Extent of LV involvement that usually results in cardiogenic shock
Infarction >40%
35
Most common complication of angioplasty
Restenosis
36
Most common thrombi found in NSTEMI(composed mainly of platelets)
White thrombi
37
Most common thrombi found in STEMI(composed of cells and fibrin)
Red thrombi
38
Most common cause of sudden cardiac death
Coronary artery disease
39
Most common arrhythmia post-MI
Premature ventricular contraction(PVC)
40
Most common lethal arrhythmia post MI
Ventricular fibrillation