Gastritis* Flashcards
What is gastritis
Inflamed stomach lining caused by mucosa injury
What are the common causes of Gastritis
H.Pylori infection
NSAIDs and Aspirin
Autoimmune
Crohn’s in children
What causes the acute onset of gastritis
Autoimmune Inflammation of the Gastric mucosa
- H Pylori
- NASAIDs
- Mucosal ISCHEMIA
- Camplyobacter
What causes the chronic onset of gastritis
Inflammation causes epithelial metaplasia
This Mucosal atrophy causes gland loss
If the metaplasia becomes dysplasia gastric cancer can occur
How can H.Pylori cause Gastritis
- Decrease SOMATOSTATIN
- Decrease HCO3
- Secrete UREASE = UREA TO AMMONIA
- Increase GASTRIN release
How can NSAIDs cause gastritis
Inhibit COX so less prostaglandins so less mucus production
How can autoimmune gastritis cause pernicious anaeamia
Fundus and stomach body affected and causes atrophic gastritis
Parietal cells decrease = Intrinsic factor deficient
Decrease B12 uptake = Pernicious anaemia
What are the Risk factors for Gastritis
Alcohol NSAIDs Poor sanitation Reflux and hiatus hernia Crohn's Zollinger-Ellison (Increase stomach acid)
What are the clinical signs of gastritis
Epigastric pain w/ diarrhoea
Indigestion/ N+V
Haematemesis and Melaena
How can you prevent gastritis
PPI alongside NSAID
What are some complications of Gastritis
Gastric cancer
Achlorydia (Decrease HCL in stomach)
Vit D deficiency
How would you investigate H.Pyloric gastritis
ClO test
Urea breath test
Stool antigen test
Endoscopy with Biopsy (Gastric cancer)
How would you investigate Autoimmune Gastritis
Anti-IF antibody
Anti-Parietal cell antibodies
Raised Gastrin
Reduced pepsionogen
What is the gold standard investigation for Gastritis
Endoscopy with biopsy
How would you manage Gastritis
Remove the cause (alcohol, NSAID.....) H Pylori = CAP Triple therapy H2 antagonist. (Decrease acid) -Ranitidine and cimetidine PPI (Decrease acid) -Lansoprazole and omeprazole
