Gastric Ulceration - control of acid secretion

Question 1

Give two examples of H2 receptor antagonists used in the control of acid secretion

Answer 1

Cimetidine

Ranitidine

Question 2

What are the mechanisms of action of Cimetidine and Ranitidine?

Answer 2

Block cAMP so reduce basal and food stimulated acid secretion.
They reduce both the volume of gastric juice secreted and its hydrogen ion concentration

Question 3

How are Cimetidine and Ranitidine administered?

Answer 3

orally

Question 4

What are the side effects of Cimetidine and Ranitidine?

Answer 4

Cytochrome p450 inhibition

Decreased sexual male function because it has some effect on androgen receptors so can reduce sperm count

Question 5

Give an example of an M1 receptor antagonist used in the control of acid secretion

Answer 5

Pirenzipine

Question 6

What is the mechanism of action of Pirenzipine?

Answer 6

It reduces basal and food stimulated acid secretion.

As efective as cimetidine in healing duodenal and gastric ulcers

Question 7

How is Pirenzipine administrated?

Answer 7

given orally

Question 8

What are the side effects of Pirenzipine

Answer 8

dry mouth