Gastric Tumors Simplified Flashcards
Benign gastric tumors
Inflammatory/Hyperplastic
Fundal
Gastric adenoma (intestinal/foveolar)
Malignant gastric tumors
Gastric adenocarcinoma
Lymphoma
Carcinoid
GIST
50-60 years
H pylori
Reactive growth post injury
> 1.5 cm risk for dysplasia
Inflammatory/Hyperplastic
Caused by PPIs or FAP
Gastrin increased
Glandular hyperplasia
Fundal polyp
Chronic gastritis
Intestinal metaplasia -> dysplasia
Located in antrum
Gastric adenoma (intestinal/foveolar)
Gastric adenocarcinoma risk factors
55
M>F
US, Japan
Blood type A
Diet
Toxins
H pylori
Gastritis
Inflammation, ROS
gastritis -> atrophy -> metaplasia -> dysplasia
Exophytic, ulcerated
Lesser curvature of pylorus, antrum, cardia, body and fundus
Adenocarcinoma Intestinal Type
No precursor lesion
EBV not H pylori
Makes Krukenberg tumors
Diffuse linitis plastica -> flattening of rugal folds, signet ring appearance from mucus around nucleus
Gastric adenocarcinoma Diffuse Type
Extranodal MALToma
Diffuse Large B cell
NHL association with EBV, H pylori
Gastric Lymphoma
Gastric MALToma
From neural crest cells and G cells in stomach
Ki67
Most common in the jejunum
Carcinoid
Most common mesenchymal
Comes from Interstitial Cells of Cajal or GI pacemaker
c-KIT kinase activation Tyrosine Kinase
50% in stomach
Epitheloid, spindle shaped
Tx Imatinib
GIST
