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GI Physiology > Gastric Secretion > Flashcards

Gastric Secretion Flashcards

1
Q

What is the function of the fundus?

A

Storage

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2
Q

What is the function of the body?

A

Storage, mucus, HCl, pepsinogen and intrinsic factor

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3
Q

What is the function of the antrum?

A

Mixing/grinding and gastrin

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4
Q

What is the Neurocrine control of gastric acid secretion?

A

Vagal innervation

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5
Q

What is the endocrine control of gastric acid secretion?

A

Hormone- gastrin

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6
Q

What is paracrine control of gastric acid secretion?

A

Histamine

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7
Q

What does the cephalic phase do to stimulate gastric acid secretion?

A

Sight, smell and taste of food. Involves the vagus nerve
Ach-Parietal cells
G-cells-Gastrin-Parietal
Ach/gastrin-ECL cells-Histamine-Parietal cells

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8
Q

What does the gastric phase do to stimulate gastric acid secretion?

A

Vagal/enteric- Ach- Parietal
Peptides in lumen- G-cells-Gastrin-Parietal
Gastrin/Ach-ECL-Histamine-Parietal

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9
Q

What does the cephalic phase do to inhibit gastric acid secretion?

A

Stop eating- decrease vagal activity

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10
Q

What does the gastric phase do to inhibit gastric acid secretion?

A

When the pH decreases, the level of gastrin decreases

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11
Q

What are enterogastrones?

A

Hormones released from gland cells in duodenum

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12
Q

Name three enterogastrones

A

Secretin
Cholecystokinin
GIP

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13
Q

What are enterogastrones released in response to?

A

Acid
Hypertonic solutions
Fatty acids
Monoglycerides

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14
Q

What are the 2 strategies of enterogastrones?

A

Inhibit gastric secretion and reduce gastric emptying

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15
Q

What is the name of the inactive derivative of pepsinogen?

A

Zymogen

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16
Q

What does zymogen storage prevent?

A

It prevents cellular digestion

17
Q

What is pepsin secretion controlled by?

A

Gastrin
Histamine
Ach

18
Q

What does a low pH convert pepsin to?

A

Pepsinogen

19
Q

What is gastric mucus produced by?

A

Surface epithelium and mucus neck cells

20
Q

What is the function of gastric mucus?

A

Protects the mucosa from mechanical injury

21
Q

Name the 3 functions that a neutral Ph in the stomach protects against

A

Gastric acid, corrosion and pepsin digestion

22
Q

What is the role of the intrinsic factor?

A

Binds with vitamin B12 in the stomach which is then absorbed in the ileum

It ensures that the erythrocytes have a biconcave disc shape

GI Physiology (6 decks)

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