Gas Exchange 2 Flashcards
What are metalloproteins
Proteins, like hemoglobin, that bind O2 to their heme group
What increases O2 carrying capacity of blood
Metalloproteins
Where is hemoglobin located
Red blood cells
What is hemoglobin
Tetramer - 4 polypeptide chains each containing a heme group.
What is the molecule called after O2 binds to a heme group
Oxyhemoglobin
Each hemoglobin can carry how many O2
4 O2 molecules
When is hemoglobin in relaxed state (R)
When it is bound to O2
When is hemoglobin in tense state (T)
When it is not bound to O2
What affects O2 equilibrium of hemoglobin
pH (Bohr effect)
What are two ways to alter hemoglobin content of blood
- Physiological acclimatization
2. Developmental acclimatization
What decreases the affinity of hemoglobin for O2 and increases O2 availability to tissue cells
- Increased temperature
- Increased CO2
- Decreased pH
- Increased 2,3 diphosphoglycerate (2,3 DPG)
What does 2,3 DPG do
Allosterically regulator of hemoglobin (decreases affinity for O2)
What generates 2,3 DPG
Red blood cells
Increased CO2 in tissues =
Decreased pH (more protons, more acidic)
When Po2 is decreased, what do red blood cells do
Increase production of 2,3 DPG