fungus 4 Flashcards
what are the 3 common pathogenic species of aspergillosis
- aspergillus fumigatus (most common)
- aspergillus flavus
- aspergillus niger
the spectrum of diseases of aspergillosis is attributed to what factors?
- allergy
- colonization
- tissue invasion
aspergillosis can be found where
everywhere; but ubiquitous in the environment
if aspergillosis colonization is a problem in what type of patients
- asthma
- cystic fibrosis
- chronic sinusitis
- chronic obstructive airway disease
- cavitary lung disease
If an aspergillosis infection colonizes and becomes invasive what can occur
- acute pneumonia
- chronic necrotizing pneumonia
- dissemination
who is at risk for aspergilloma (ball of fungus sitting in lung)
chronic sinusitis
chronic obstructive airway disease
cavitary lung disease
what are the risk factors for allergic bronchopulmonary aspergillosis
cystic fibrosis and asthma
what are the risk factors for aspergilloma
underlying lung diseases:
chronic sinusitis
chronic obstructive airway disease
cavitary lung disease
what are the risk factors for invasive aspergillosis
immunocompromised status
what are the risk factors for chronic pulmonary aspergillosis
underlying lung disease
what are the risk factors for superficial aspergillus infections
immunocompromised status
what are the problems for cultures when diagnosing aspergillosis
cultures are often false negatives
what is a helpful diagnosis tool for aspergillosis
galactomannan antigen test
very sensitives so negative = safe; positive = maybe
what is the treatment for invasive pulmonary aspergillosis (IPA)
voriconazole
what is the treatment for invasive sinus aspergillosis
voricaonazole
what is the prophylactic therapy for invasive aspergillosis
posaconazole
what is the treatment for chronic cavitary pulmonary aspergillosis
itraconazole or voriconazole
what is the treatment for allergic bronchopulmonary aspergillosis (no infection; allergic reaction)
itraconazole
what is the treatment for aspergilloma
no therapy; surgical intervention may be required
what aspergillus relatedconditions is voriconazole the primary therapy
- IPA (invasive pulmonary aspergillosis)
- invasive sinus aspergillosis
- tracheobronchial aspergillosis
- chronic necrtizing pulmonary aspergillosis
- CNS aspergillosis
