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Microbiology > Fungi > Flashcards

Fungi Flashcards

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Biology 101 flashcards
1
Q

KOH prep

A

Dermatomycoses

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2
Q

Red patches with clear borders, sometimes ring like appearance

A

Dermatomycoses

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3
Q

Dermatomycoses uses what to invade skin?

A

keratinases

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4
Q

ROSES

A

Sporotrichosis

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5
Q

What does sporotrichosis look like under microscope?

A

Flowerette

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6
Q

Tumor like swollen lesions that form draining sinus tracts and SULFUR granules

A

Myetoma

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7
Q

Bird/Batz

A

Histoplasmosis Capsulatum

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8
Q

Wind/SW USA

A

Coccidioidmycosis

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9
Q

ICH to SE asia

A

Pencilliosis

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10
Q

Bread mold

A

Zygomycosis

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11
Q

Zygomycosis vs. aspergillosis?

A

zygo 90

asp 45

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12
Q

Catheters, biofilm?

A

Candidiasis

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13
Q

Pigeon, encapsulated so india ink, CNS

A

Cryptococcosis

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14
Q

How is pneumocytosis difefrent than other fungi?

A
  1. Susceptible to antibacterial agents
  2. Lacks ergosterol
  3. Not susceptible to amphotericin B (which targets ergosterol)
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15
Q

What population gets PCP?

A

Only ICH

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16
Q

o Binds sterols and punches wall in membrane
o Nephrotoxic
o Lipid form (Ambisome) less toxic doe

A

Amphotericin B

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17
Q

o P450 inhibitors that block conversion of lanosterol to ergosterol, interfering with fungal cell membrane synthesis

A

Azole

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18
Q

which of the azole has SE of visual disturbance?

A

Vorixonazole

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19
Q

o Inhibits synthesis of 1,3-D-glucan, component of fungal cell wall
o Few SE because enzymatic pathway not found in humans
o Candida and Aspergillus treatment

A

Echinocandins

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20
Q

o DNA synthesis inhibitor
o Used in combo with amphotericin B
o Treats cryptococcal meningitis and some cindida
o SE: fatal bone marrow suppression

A

Flycytosine

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21
Q

o Interfered with ergosterol synthesis by inhibiting fungal squalene epoxidase
o Only achieves concentrations in skin and nails
o Tx for onychomycosis and fungal dermatophyte infections

A

Terbinadine

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22
Q

Dimorphic Fungi?

A

Histoplasmosis Capsulatum
Blastomycosis dermatitidis
Coccidiomycosis
Paracoccidioidomycosis

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23
Q

Sulfur granules

A

P. Boydii

24
Q

Traumatic implantations

A

P. Boydii or Sporotrichosis

25
Q

tuberculate macroconidia

A

Histoplasmosis Capsulatum

26
Q

Urine Ag

A

Histoplasmosis Capsultaum

27
Q

Suppuration (Abscess) that can get into bones, CNS, skin

A

Blastomycosis dermatidis

28
Q

Dimorphic fungi transmission?

A

inhalation

29
Q

Broad based budding yeast cell

A

Bastomycosis dermatitidis

30
Q

Valley fever SQ USA

A

Coccidio

31
Q

Rounded spherules with nonbudding endospores

A

Coccidio

32
Q

Rectangular bricks

A

Coccidio

33
Q

Ships’s wheel

A

Paracoccidio

34
Q

Diabetes

A

Zygomycosis

35
Q

Zygomycosis tx?

A

Amphotericin B

36
Q

fungal ball, fruiting head

A

Aspergillosis

37
Q

Aspergillosis tx?

A

Caspofungin

38
Q

Mannan in cell wall

A

Candidiasis

39
Q

thrush

A

candidiasis

40
Q

Myeloperoxidase

A

Canidiasis

41
Q

Antiphagocytic capsule

A

crytpococcosis

42
Q

punched ping pong balls on silver stain

A

PCP

43
Q

PCP tx?

A

Treimethoprim and sulfa

44
Q

Amphotericin B does not work against what?

A

P. Boydii

45
Q

Nephrotoxic

A

Amphotericin B

46
Q

Oral candidiasis

A

Nystatin

47
Q

Azole works how?

A

fungal cell membrane synthesis of ergosterol p450 inhibitor

48
Q

which azole decreases libido?

A

Keto

49
Q

Asperigillus using Azole (which 2)

A

Itraconazole and Voriconazole)

50
Q

Which azole against zygomycetes

A

Posaconazole

51
Q

Caspofungin, Micofungin, Anidulafungin examples of what?

A

Echinocandins

52
Q

Echinocandins work how?

A

inhibits synthesis of fungal cell wall

53
Q

Echinocandins used in treatment of what 2?

A

Candida and aspergillus

54
Q

SE of fatal bone marrow suppression

A

Flucytosine

55
Q

inhibits squalene epoxidase?

A

Terbinadine

56
Q

dermatophyte infection tx?

A

Terbinadine

Microbiology (8 decks)

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