Antivirals

Question 1

Enfurvitide

Answer 1

Fusion inhibitor of CD4 cells

Question 2

Treats influenza A/B

Answer 2

Oseltamivir, zanamivir

Question 3

Emtricitabine

Answer 3

NRTI

Question 4

BM suppression

Answer 4

NRTI

Question 5

Lamivudine

Answer 5

NRTI

Question 6

Treats CMV

Answer 6

Gancyclovir

Question 7

CMV retinitis in ICH, acyclovir resistant HSV (after foscarnet): nephrotoxicity: inhibits viral DNA Polymerase; does not require phosphorylation

Answer 7

Cidofovir

Question 8

Major toxicity: lipodystrophy

Answer 8

Protease inhibitors

Question 9

Nevirapine

Answer 9

NNRTI: reduced maternal-fetal transmission

Question 10

How does neuramidase inhibitors work?

Answer 10

prevents viral release

Question 11

Indinavir

Answer 11

protease inhibitor -navir

Question 12

Interferon (PEG)

Answer 12

Alpha: chronic hepB/C, Kaposi’s sarcoma; beta: MS gamma: NADPH Oxidase deficiency SE: neutropenia glycoproteins from human leukocytes block viral RNA/DNA synthesis (induce nuclease that degrade viral mRNA

Question 13

Amantadine

Answer 13

Influenza A (neurologic SE: interferes with viral protein M2 required for uncoating)

Question 14

CMV (especially ICH): viral kinase phosphorylates guanosine analog inhibiting viral DNA polymerase HEMATOLOGIC SE (neutropenia/leucopenia)

Answer 14

Ganciclovir

Question 15

HepC, RSV, hemorrhagic fever: SE anemia and teratogen; inhibits synthesis of G nt by inhibiting IMP dehydrogenase

Answer 15

Ribavirin

Question 16

Efavirenz

Answer 16

NNRTI

Question 17

Lactic acidosis toxicity

Answer 17

NRTI

Question 18

NRTI pancreatitis

Answer 18

Didanosine

Question 19

Steven-Johnson syndrome toxicity

Answer 19

NNRTI

Question 20

Tenofovir

Answer 20

NRTI: doesn’t need to be phosphorylated

Question 21

Influenza A: neurologic SE, interferes with viral protein M2 required for uncoating

Answer 21

Rimantadine

Question 22

Better oral availability than acyclovir: NOT CNS-thymidine kinase (by virus) phosphorylates guanosine analog inhibiting viral DNA polymerase

Answer 22

Valacyclovir

Question 23

Zidovudine

Answer 23

NRTI: (AZT): reduce maternal-fetal transmission

Question 24

HSV/VZV (PO: genital, IV: encephalitis): thymidine kinase (by virus) phosphorylates guanosine analog inhibiting viral DNA polymerase; RENAL CNS SE

Answer 24

Acyclovir

Question 25

Hypercholesterolemia toxicity

Answer 25

Integrase inhibitors

Question 26

Ribavirin used for

Answer 26

Hep C, RSV, hemorrhagic fevers

Question 27

Delaviridine

Answer 27

NNRTI

Question 28

Hep B tx?

Answer 28

Lamividine, Adefovir, or INF-alpha

Question 29

Hep C tx?

Answer 29

Ribavirin

Question 30

HAART tx?

Answer 30

Lamividine