Functional Anatomy Of Mood Disorders Flashcards
What part of the striatum relates to emotional processing?
Ventral striatum (dorsal is involved in motor coordination)
What social/emotional changes would you see in someone with posterior cortical atrophy?
You shouldn’t see any as the posterior brain isn’t involved in emotional regulation. (Contrast with FTD where first signs are inappropriate social behaviour).
What are the limitations (and solutions) of BOLD fMRI studies?
Different subjective experiences
In what people is the subgenual cortex more active?
Those more likely to give to charity.
Those prone to guilt or empathic concern.
(Abnormal metabolism in those experiencing major depression)
How does guilt express in depression?
Overgeneralisation of blame or guilt only to themselves, leading to self-worthlessness
What is the view of depressive aggression in diagnostic categorisation?
Outward aggression in MDD is relatively rare and not a diagnostic feature.
Non violent irritability and anger in typical depression is linked to rejection sensitivity and low self worth.
How does dysfunction in the right anterior superior temporal lobe manifest?
Dysfunction in interpreting social behaviour.
Underactivity (FTD) inappropriate behaviour
What dopaminergic area remains relatively intact in Parkinson’s?
Mesolimbic pathway - ventral tegmental area to limbic system and frontal lobe
What cognitive distortion makes people vulnerable to depression?
Blaming oneself in over general fashion
What part of the brain is associated with social conceptual knowledge and specific critique?
Right superior anterior temporal lobe
(atrophied in FTD)
(Cross-talk with subgenual disrupted in MDD)
What is the problem with overfitting in standard models?
The model will represent the quirks of the sample rather than the relationship between variables
How does blame rebalance neurofeedback work?
Reinforced increasing connection between superior anterior temporal lobe and subgenual cortex
What Brian area responds to negative faces?
Amygdala
What symptom to most people with treatment resistant depression have?
Anxious distress
