FSII mod 2 Flashcards
phagocytes are and do what
- neutrophil, monocyte, macrophage, dendritic cell
antibacterial immunity and cell bacterial infections
FC gamma R3A (CD16A)
antibody dependent cell mediated cytotoxicity (ADCC).
NK cells for virus and tumor THIS IS APOPTOSIS
FC epsilon RI
HIGH AFFINITY ADCC with IgE and Eosinophil AND some IgG
Helminth death
FC epsilon RI and mast cells
Mast cells increase mucous, intestinal mobility, recruit inflame, secretion of IL5 leading to more production of eosinophils
- for microbes
FC epsilon RI and eosino
IgE bound by FC epsilon Rs on eosino leading to degranulation and release of proteins
Fab portion reacts with epitopes on helminth and FC region binds to receptors of eosino.
c3a,4a,5a
are NOT attached to cell surfaces and increase perm of blood vessels along with IgG and IgM
Involves mast cell, neutrophils, monocyte and macrophage
**3 and 5 do mast dell degranulation during IgE stim
c3b
s attached to surface. Bacteria is coated with it and IgG then brings it to FC gamma RI receptor to do lysosome
Neutrophil and macrophage
b cell class switch IFNy
IgG
b cell class switch Il4
IgE
b cell class switch TGF b
IgA
- esp in mucosa
describe MHC
heterodimeric glycoproteins composed to 2 noncovalently associated polypeptide chains and have a groove for peptide binding site
what has MHC class 2
Found on B cell, macrophage, dendritic cells and activated T cells thymus epi
cd4 differentiation Il 12
Th1
cd4 differentiation Il 4
th2
il 2 t cells
autocrine clonal selection
dendritic cells uptake antigen
VIRUS uptake antigen via macropino and phago and MHC strongest on lymph tissue. FOR PROTEIN ANTIGENS
MACROphage uptake antigen
BACTERIA uptake antigen via phase, MHC can be induced by bac. FOR CELL MEDIATED RESPONSE
b cells uptake antigen
antigen uptake unique since endocytosis, cut it and present to CD4 ALSO activates itself. FOR HUMORAL IMMUNE RESPONSE TO CD4
antigen processing and presenting MHC class 2
XCELL endocytosis to phagolyso then presented to CD4 cell
antigen processing and presenting MHC class 1
mostly intracell and in proteasome already then presented to CD8
- self proteins, viral, intracell bac, fungi and parasites or tumors
th1 cells
- IFNY
activate macrophage and elim intracell path OPSONIN
Effector fun: antigen receptor, then APC cytokines and ligand interaction then IL2 to autoprolif then IFN y to class switch to IgG, macrophage activation and complement
Good for intracell bacteria that live in phagosomes of phagocytes!!!
They stim the phagocyte to kill the bacteria itself, no two signals needed.
After, it also increase expression of moles for T cell activation, secretion of inflame cytokines to bring in more WBC
- TB CELLS and the granuloma!!!! and delayed hypersensitivity
th2 cells
Il4 and 5
phagocyte independent immune fins
Effector fun: HEMLINTHS/incell paths
Il4 to stim macrophage for TISSUE REPAIR, make mucous and move intestine AND class switch to IgE and mast cell degranulation
Il5 for eosinophils
th 17
incude inflam, make antimicrobial peptides aka defensins.
treg
Maintain tolerance against self when bad T cells get OUT of 1 organ