BSI mod 2 Flashcards
voluntary NS
ach, skeletal, nicotinic M cholinergic, myelinated
curare and gallamine
nicotinic M blocker. comp but non depolarizing,
- ach can be increased by anticholinesterase (phisostigmine)
succinylcholine
nicotininc M blick, irriversible, short lasting, depolarizing non comp, degraded by cholinesterase eventually
- patients must be ventillated
anticholinesterase
neostigmine
- increase ACH everywhere. alzheimers, treat myasthenia gravis, muscle contraction since its agonist. reversible
- could work for xerostomia but increases contraction so not best
novichok
irrversibly binds cholinesterase. increases ach. sludge (musccarinic agonist) increase parasymp and blocks NMJ
* atropine antidote but not for muscccle paralysis
parasymp
long pre gang, short post gang from sacral spine
- ach is pre and post
- nicotininc N and muscarinic
- pupil small (myosis), bronchi, HR, sweat also down
symp
lumbar of spine is short pre gang, long post (many), pre NT is ach, post is NE, E, ACH
- nicotininc N
alzheimers
donepesil anticholinesterase
- glutamate too
atropine
muscarininc antagonist. dries mouth. pupil dialate (mydriasis), decrease sweating since less ach, increase HR, decrease bronchi, increase symp
** doesn’t block skeletal muscle
pilocarpine
muscarininc agonist. increase saliva for xerostomia. miosis, increase sweat and down hr, more poops
benadryl or scopolamine
muscarininc antagonist to stop motion sickness (stomach and ear). pass BBB. lower ACH, increase dopamine! antishistamine
- doesn’t work for opioids since doesn’t block dopa and serotonin too
alpha 1
everything tight on skin and mucous
prazoin (minipres)
block alpha 1 so vasodilate and bp (orthostatic hypotension)
phentolamine (oraverse)
nonselective block for alpha 1 and 2. tachycardia because of alpha 2. speeds up recovery and lip freeze
doxazosin, terazosin
block alpha 1. hypertension treatment (orthostatic problem)
tamsulosin (flomax)
alpha 1 selective. increase pee for prostate
alpha 2
DECREASES bp by stopping NE release
clondine (catapres)
stim alpha 2 so decrease Ne release and lower bp
beta 1
tight again. increase HR AND contraction force
epinephrine
agonist of alpha 2, b1 and 2. NOT in CNS from BBB. mixed with lidocaine. high HR but no hypertension for B2
propanolol (inderal)
block beta 1 and 2. slow HR. treat hypertension but blocks beta 2 so vasoconstriction
metoprolol
selectie beta 1 block so slow HE and contraction force
which 2 receptors are opposive
muscarinic M (para_) and Beta 1 (symp)
beta 2
bronchodilation. vasodilate muscle and organs.
albuterol (proventil)
agonist of beta 2. anti asthma NOT beta 1. no heart stim
atropine –> ipatropium (atrovennt)
also asthma. muscarinic antagonist so dry mouth.
* can’t pass BBB so no CNS or motion sickness blcik
l dopa synthesis
- tyrosine to dopa to dopamine then norepi (add OH) then epi (add methyl)
stop L dopa breakdown
methyl transferase inhibitor
carbidopa
stops dopa conversion OUTSIDE brain (so not for parkinsons)
what locks dopamine reuptake
cocaine
how to treat depression
block MAO, block NE reupta)ke and serotonin (kinda like cocaine)
parkinsons treatment
inhibit L dopa breakdown in brain. block COMT (C for cranial)
- benadryl to stop muscarinic . l dopa to increase dopamine, benztropine to stop muscarinic
- always HIGH muscarinic, low dopamine
nicotine
N and M agonist. increase dopamine