Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Noorda FOM > FOM Module 2 > Flashcards

FOM Module 2 Flashcards

1
Q

Ways to covalently modify histones (2.4)

A

Methylation
Acetylation
Phosphorylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where on the DNA strand does methylation occur? (2.4)

A

Cytosine in CG-rich sections (CpG islands)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What molecule is used as the methyl donor in DNA? (2.4)

A

S-adenosylmethionine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Active genes are (hypo/hyper) methylated? (2.4)

A

Hypomethylated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is gene amplificaiton? (2.4)

A

When genes are inserted into other DNA sections and produced by those sections resulting in overexpression of said protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Segments of genes in B-lymphocytes that are rearranged? (2.4)

A

(V) Variable
(D) Diversity
(J) Joining

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is an enhancer? (2.4)

A

DNA palindromes or tandem repeats that speed up the transcription rate of a gene when paired with an activator.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is a transcription factor? (2.4)

A

A protein necessary in the transcription process that regulate the rate of mRNA transcription

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is a repressor? (2.4)

A

Proteins that slow down or stop the transcription of mRNA under certain conditions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where are regulatory sequences usually found? (2.4)

A

Noncoding regions of DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the structural DNA binding proteins? (2.4)

A

Zinc Fingers
Leucine zippers
Helix-turn-helix
Helix-loop-helix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are zinc fingers? (2.4)

A

2 alpha helix and beta sheet dimers with zinc chelated at 4 positions by histidine or cysteine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are leucine zippers? (2.4)

A

alpha helix diner with leucine every 7 acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is a helix-turn-helix? (2.4)

A

One alpha helix in the DNA curve with 2 more laying across (not a dimer)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is a helix-loop-helix? (2.4)

A

2 alpha helix dimers similar to leucine zippers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the code for early degradation in RNA? (2.4)

A

5’ AUUUA 3’

17
Q

What are the steps of the hormone response element (HRE)? (2.4)

A
  • Transactivation domain (TAD) binds coactivators
    -TAD and coactivators bind DNA binding domain (DBD)
    -TAD/DBD (ligand) bind to the ligand binding domain (LBD)
    -LBD group binds to nuclear localization signal (NLS) and enters the nucleus
18
Q

What are the transcriptional regulators for steroid receptors? (2.4)

A

HSP - heat shock proteins
GRE - glucocorticoid response element
GR - glucocorticoid receptor

19
Q
A

Noorda FOM (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions