fluids and mostly cancer still Flashcards

1
Q

EDEMA

A
Excess fluid in interstitial (intercellular) spaces or body cavities
Depending upon its contents
Transudates
Exudates
Depending upon its locations and extent
Localized
Organs
Existing cavities
Generalized
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2
Q

Transudates

A

fluid accumulations which are essentially salt and water (low protein, few cells)

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3
Q

what are the causes of transudates

A

CAUSES

  1. increase fluid volume
  2. increase (hydrostatic) pressure
  3. decrease plasma proteins (decrease oncotic pressure)
  4. Lymphatic blockage
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4
Q

increased fluid volume

A

 fluid volume:

a) Kidney failure (retention of sodium)

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5
Q
  1. increase (hydrostatic) pressure with in the veins
A

a) Legs (prolonged standing);

b) Generalized (heart failure)

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6
Q

HYPERVOLEMIA

A

Excess water in extracellular space
Retention of water and Na – Congestive heart failure, liver cirrhosis, renal failure, excessive fluid replacement
EDEMA: Increase in the interstitial fluid (local, generalized). Excess third space fluid may also be included in this definition

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7
Q

HYPOVOLEMIA

A

Deficit of body fluid volume.
Loss (including hemorrhage), reduced intake, loss into third space
Dehydration: Result of decreased extracellular fluid (or increased Na+ in relation to water – hypertonic condition)

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8
Q

Hemorrhage

A

Hemorrhage: Blood has escaped from blood vessels

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9
Q

Hematoma

A

Hematoma: Leaked blood enough to form a mass

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10
Q

benign vs malignant

A

bening will be painful, the same colour as the tissue, will grow slow in most cases.
malignant will be different colours- painless, grow quickly , will most likely spred

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11
Q

how we name it, why do we need to distinguishe, chemical presentation- ulcers…, paraneoplasmic - not normaly expressed, displasia, desmoplasia,

A

need to know

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12
Q

treatment of cancer

A

surgery, radiation- for radiosensitive tumors- shrink tumor fast exemple- on neck and stoping breathing, chemotherapy- drugs that destroy the cancer cells- destroys normal cells aswell, other- experimental

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13
Q

why do cancers occur

A

DNA damage,

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14
Q

preneoplasmic

A

precancer, example of displasia

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15
Q

preneoplasma

A

stage in the early development of cancer

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16
Q

CARCINOGENESIS

A

CARCINOGENESISEnvironmental and Hereditary factors play important roles in causing genetic changesSome patients develop PRENEOPLASTIC LESIONS
Pathologic “space occupying lesions” that can evolve into frank neoplastic process
E.g. Colonic polyps
Majority require environmental insults
Some may be inherited from parents
Syndromes of defective DNA repair (e.g. ataxia telangiectasia)

17
Q

cancer developmetn

A

turning off (hemosuppressor genes) turning on- - oncogene

18
Q

tumor growth

A

normal cells becomes a transformed cell (ireversibly cancerous cell)- divides 30 times and it will become clinical detection of 1cm/1g - this is where it will show the symptoms (anorexia, )- divides 10 more time and will be 1kg and will be fatal
this is why it is best to identify early

19
Q

breast cancer takes 2 month for 1 doubling

lung takes 150 days

A

not as effetive with chemo because takes a long time to devide

20
Q

colon cancer takes 80 days but burkits lymphoma (1 day)or choriocarcinoma

A

dont need to know

the fast ones can be cured because chemo works better-

21
Q

burkit lymphoma

A

BURKITT’S LYMPHOMAThe fastest growing human tumor

in jaw- tumor of the b cells

22
Q

angiogenesis- forming there own blood supply

A

Blood supply is essential for tumor growth.
1-2 mm is maximum diffusion distance
Necrosis is common in tumors > 2mm in size.
Access to blood vessels is necessary for metastasis.
Angiogenic factors: FGF, VEGF etc.
Clinical importance:
Anti-angiogenic drugs
Block off a blood vessel supplying the tumor

23
Q

1: can take away blood supply or

A

can give them drugs to stop new blood supply of being formed

24
Q

cancer prevention

A
Lifestyle
BALANCE
Physical: Diet, exercise
Psychological
Social
Proactive health management
Regular physicals