Fluid Flashcards

1
Q

How much of our body composed of water

A

60%

Makes body weight sensitive to fluid status

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2
Q

3 spaces within the ECF

A

Interstitial (around cell out of vessel)

Intravascular (in BVs)

Transcellular (third spacing)

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3
Q

The proper distribution of water among body compartments is strongly related to what?

A

The number of osmoles present in the ECF

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4
Q

Osmoles

A

Drawl water into its direction

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5
Q

Normal concentration of osmoles in the ECF is

A

275-295

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6
Q

How do we assess fluid and electrolyte status?

A

Blood sample

Test the liquid components of blood (plasma and serum)

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7
Q

Plasma

A

Liquid component of blood

Plasma proteins and all other particles dissolved in the blood

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8
Q

Serum

A

Liquid component of blood

Remains in the blood sample after a blood clot is allowed to form

Does not contain:
The coagulation proteins used to form the clot

Does contain :
-Other plasma proteins (antibodies, hormones)
-Dissolved particles (glucose, electrolytes, O2 & CO2)

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9
Q

Osmolarity vs osmolality

A

Osmolarity: miliosmoles per liter (IV solutions)

Osmolality: milliosmoles per Kilogram (human body)

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10
Q

Osmosis

A

Movement of water across a semipermeable membrane

Plasma membranes of cells are:
Freely permeable to water
Relatively impermeable to sodium

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11
Q

When osmolality is off look at what three things

A

Na
Glucose
BUN

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12
Q

Normal serum sodium

A

140

Sodium x 2 = osmolality (140x2=280)

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13
Q

Isotonic

A

Same as normal, healthy plasma

Normal osmolality=275-295

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14
Q

Hypotonic

A

ECF tonicity too low

Swells cell

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15
Q

Hypertonic

A

ECF tonicity too high

Cell shrinks

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16
Q

Edema

A

Collection of fluid in the Interstitial space

Fluid moves in and out of capillaries (governed by “Starlings Law of the Capillaries)

17
Q

Colloid

A

Large molecular weight particles (proteins)

Do not dissolve in water

18
Q

Crystalloid

A

Particles that dissolve when added to water to form a true solution

19
Q

Hydrostatic pressure (fluid pressure) vs osmotic pressure

A

Hydrostatic pressure: fluid pushing outward on the vessels
*force favoring filtration/pushing fluid out

Osmotic pressure : proteins (colloids that cause a pulling force causing pressure
*force favoring reabsorption/pulling fluid in

20
Q

What does the lymph system do in the starlings law of the cappilaries

A

Drawls in the extra fluid

21
Q

Mechanisms of edema formation

A

1) increased capillary hydrostatic pressure (BP)

2) decreased capillary colloid osmotic pressure (decreased proteins=cant reabsorb)

3) increased capillary permeability (inflammation, allows more things to leave)

4) obstruction of lymphatic flow (called lymphedema) skin of an orange

22
Q

Third spacing

A

Fluid shifting into transcellular spaces

Ascites (peritoneal cavity)

Pleural effusions (pleural space)

Pericardial effusions (pericardial space)

23
Q

Antidiuretic Hormones (Arginine Vasopressin)

A

Triggers retention of water by pores

travels thru blood to kidneys to increase retention of water bu inserting more awuaporin proteins into renal tubule cells

24
Q

Pathophysiologic conditions of ADH secretion

A

Diabetes insipidus (arginine vasopressin deficiency)

Syndrome of inappropriate ADH (SIADH)

25
Q

Diabetes Insipidus (arginine vasopressin deficiency)

A

Insufficient ADH

Excessive renal excretion with increased thirst

Risk of hypovolemia and hypernatremia

26
Q

Syndrome of inappropriate ADH (SIADH)

A

Excessive ADH

Excessive renal retention

Hypervolemia with hyponatremia

27
Q

Fluid volume excess

A

Typically hypotonic and hyponatremic

Fluid dilutes

28
Q

Fluid volume deficit

A

Associated with various levels of tonicity