Flash Cards from online work - Urinary
Which of the following describes the location of the kidneys?
Retroperitoneal at the level of T12 to L3
How do the kidneys regulate blood volume and blood?
By regulating water output
The process of separating wastes from the body fluids and eliminating them is called __________.
excretion
What is the order of urine-collecting structures found within the kidney?
Minor calyx, major calyx, renal pelvis, ureter
Which blood vessel carries blood into a glomerulus?
afferent arteriole
When there is a drop in blood pressure, the juxtaglomerular cells respond by secreting which of the following?
renin. Renin triggers chain reaction
That creates hormone angiotensin
That signals adrenal glands to release aldosterone
Your uncle has been diagnosed with renal insufficiency and placed on dialysis. He asks you why he has to take EPO now as well. What do you tell him?
Diseased kidneys no longer produce enough EPO, which can lead to anemia.
Erythropoietin - stimulates red bone marrow to make RBC’s
What is tubular secretion?
The movement of water and solutes from the blood into the tubular fluid. Transfer of materials from peritubular capillaries to the renal tubule. Opposite process of reabsorption. Secretion mainly caused by active transport and passive diffusion
If a patient presents with aStreptococcus viridansinfection, his doctor may prescribe oral penicillin taken four times daily.Why does he have to take the penicillin so often?
The renal tubules extract penicillin from the blood and secrete it into the urine. To keep enough in body so do job need to take reguraly
The primary function of the nephron loop is to generate a medullary ECF osmotic gradient that allows for what?
Elf is extra cellular fluid
The concentration of urine
A friend confides in you that she’s recently started taking a calcium supplement but then started having very painful urination. You suggest she go to a doctor to get checked for which of the following?
Renal calculi
In the kidney, tubular reabsorption refers to the movement of fluid and solutes where?
From the tubular fluid into the blood
Ie. The blood is reabsorbing the fluid hence reabsorption
Nephrons are the functional units of the kidneys, responsible for the processes of
removing wastes and excess h20 from blood
The process of glomerular filtration occurs within the
renal corpuscles of kidney nephrons.
This pressure-driven process moves materials from
the glomerulus into the capsular space across a thin, negatively charged filtration membrane.
The filtration membrane is composed of the
fenestrated endothelium of the glomerulus, the filtration slits of the podocytes found within the visceral glomerular capsule, and the porous basement membrane found between these two cell layers.
This membrane is size selective. It is permeable to smaller substances such as
ions, water, and glucose and impermeable to larger materials such as formed elements and most proteins.
systemic blood pressure drives the movement of what
movement of blood from the afferent arterioles into the glomerulus.
Changes in system blood pressure impact the blood flow into glomerulus, how do the arterioloes compensate for this
altering their diameter so that glomerular blood pressure will be maintained
as systemic blood pressure increases how does the arteriole react
decreases its diameter
Contraction resists The increased pressure
Thereby keeping blood flow consistent
as systemic blood pressure decreases how does the arteriole react
increases its diameter
By increasing in diameter compensates For reduced body in systemic system and maintains consistent flow to glomerular
the capsular space is the region where this collects
filtrate
what are the five substances that can cross the filtration membrane
urea; small protein; h20; ions; glucose; erythrocytes
Glomerular filtration is highly regulated because of its influence on
the amount of substances reabsorbed into the blood and the amount excreted in the urine.
The glomerular hydrostatic pressure (HPg) is responsible for
forcing materials through the filtration membrane from the blood into the capsular space.
Two smaller forces, the blood colloid osmotic pressure (OPg) and the capsular hydrostatic pressure (HPc), work together to
oppose HPg.
Colloid osmotic pressure - induced by proteins in blood that causes A pull on fluid back into the capillary
Capsular hydrostatic pressure - is aback pressure that opposes filtration
Cumulatively, the difference between these pressures determines
the net filtration pressure (NFP), which must be greater than zero for filtration to occur.
By being able to control the glomerular filtration, the kidney is able to control
urine production based on physiological conditions such as hydration
in order for filtration to occur the overall pressure moving outward from the glomerulus to the capsular space muse be
greater than the combined inward pressures
If both the glomerular ( HPg) and capsular hydrostatic (HPc) pressures remain unchanged, an increase in the blood colloid osmotic pressure (OPc) results in __________the net filtration pressure.
a decrease in
Which of the following forces oppose glomerular filtration?
capsular hydrostatic pressure (HPc) and blood colloid osmotic pressure (OPg)Correct
Glomerulosclerosis results in a __________ of the basement membrane.
thickening
Proteinuria occurs when the filtration membrane becomes leaky, allowing proteins to cross. This impacts the blood colloid osmotic pressure by __________ the osmolarity gradient between the blood and filtrate, thereby __________ the strength of this pressure.
decreasing; reducing results in net increase in filtration
glycosylation
plasma glucose levels become elevated, and this excess glucose can attach to proteins, as a result basement membranes of a majority of capillaries around the body are thickened and hardened by deposits of glycosylated proteins.
glomerulosclerosis
general name for hardening or scarring of the glomeruli within the kidneys is
diabetic glomerulosclerosis, not only is there thickening of the basement membranes that form one of the layers of the filtration membrane, but there is also
proliferation and expansion of the intraglomerular mesangial cells and associated matrix.
Most proteins cannot normally cross the filtration membrane due to
their large size and the negative charge of the basement membrane.
During glomerulosclerosis, however, the filtration membrane becomes a less effective barrier, allowing
proteins to enter into the filtrate. Thus, this is one of several conditions that leads to proteinuria
proteinuria
a condition in which proteins leak from blood into the urine.
The net filtration pressure (NFP) is the driving force of the
glomerular filtration process. It is responsible for pushing the filtrate into the capsular space
The glomerular filtration rate (GFR) is the measurement of
filtrate volume per unit time, normally recorded as ml/min, and is influenced by the rate of blood flow into the glomerulus.
The body quickly adjusts to changes in systemic blood pressure within a narrow range by modifying
the rate of blood flow to the glomerulus from the afferent arterioles via vasodilation and vasoconstriction – this is referred to as
the rate of blood flow to the glomerulus from the afferent arterioles via vasodilation and vasoconstriction – this is referred to as
intrinsic regulation
Extrinsic regulatory pathways include the
nervous and endocrine systems, produce their effects through neurotransmitters and hormones, and have longer lasting effects.
An increase in the NFP would result in __________the GFR
AN INCREASE IN
Renin is released in response to __________ stimulation.
SYMPATHETIC
NFP AND GFR HAVE WHAT TYPE OF RELATIONSHIP
POSITIVE CORRELATION; WHEN NFP INCREASES, GFR INCREASES
EXTRINSIC CONTROLS INFLUENCING GFR INCLUDE
NEURAL AND HORMONAL REGULATION
SYMPATHETIC NERVOUS STIMULATION CAN REDUCE GFR IN TWO WAYS _ ask hormonal is extrinsic-regulation while arterioles
Vasodilation vasoconstriction are intrinsic controls
STIMULATING VASOCONSTRICTION OF ARTERIOLES; OR STIMULALTING RELEASE OF RENIN
WHAT CELLS RELEASE RENIN
JUXTAGLOMERULAR APPARATUS
WHAT DOES RENIN CAUSE TO BE RELEASED
ANGIOTENSIN II - RESULTS IN AN OVERALL DECREASE IN THE FILTRATION SURFACE
THE HEART RELEASES THE HORMONE ATRIAL NATRIURETIC PEPTIDE (ANP) IN RESPONSE TO
INCREASES IN BLOOD VOLUME OR BLOOD PRESSURE.
ANP RESULTS IN AN INCREASE IN GFR IN THREE PATHWAYS
INHIBITION OF RENIN; DILATION OF ARTERIOLOES; INCREASE IN FILTRATION SURFACE
WHAT CAUSES FILTRATION SURFACE TO INCREASE
RELAXATION OF MESANGIAL CELLS - and causes this relaxation - relaxes basement membrane thereby increasing surface area of basement membrane and, this increases glomerular filtration rate
Renin is released from the
juxtaglomerular apparatus (JGA) cells in response to reduced renal arterial pressure, sympathetic neural stimulation, or increased sodium concentration at the distal renal tubule.
The release of renin is regulated by
sympathetic nervous system stimuli.
Renin converts the plasma protein angiotensinogen into
angiotensin I, which is then converted to angiotensin II in the lungs by angiotensin-converting enzyme (ACE).
Angiotensin II stimulates a number of pathways, including the
synthesis of the hormone aldosterone by the adrenal cortex which results in increased sodium and water retention, thus increasing blood pressure. Other effects within the kidney include 1) efferent arteriole vasoconstriction, and 2) the contraction of intraglomerular mesangial cells.
Both angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARB) decrease the
angiotensin mechanism.
ACE inhibitors directly reduce
the amount of angiotensin II being formed, while ARBs depress the effects of angiotensin II by preventing it from binding to its effector cells.
ACE inhibitors lower blood pressure mainly by
decreasing peripheral vascular resistance.
Patients with chronic kidney disease are often prescribed ACE inhibitors because
they stabilize renal function and diminish proteinuria.
Angiotensin II triggers the __________ of the intraglomerular mesangial cells, which results in a(an) __________ of the filtration surface area.
contraction; decreaseCorrect
ACE inhibitors are prescribed to control blood pressure. These drugs work by reducing __________.
the conversion of angiotensin I to angiontensin IICorrect
After blood is filtered in the renal corpuscle, the filtrate passes into
the renal tubule,
the renal tubule CONSISTS OF
which consists of three fairly distinct regions of cells specialized to promote molecular exchange between the renal tubule and the interstitial fluid.
The primary goal of the renal tubule is to
reabsorb substances into the blood that the body needs to help maintain homeostasisand to eliminate substances the body does not need or that might be toxic to the body.
In addition to urine formation, the kidneys help regulate
blood pressure by balancing the levels of water and sodium that are reabsorbed versus excreted. This is a prime example of the integrative nature of body systems.
The renal tubule consists of the
proximal convoluted tubule (PCT), nephron loop (Loop of Henle), and distal convoluted tubule (DCT).
As the filtrate moves through the renal tubules, its composition is selectively altered through the processes of
tubular reabsorption and secretion.
Materials that are reabsorbed move out of the tubular filtrate by crossing both
the luminal and basolateral membranes of the tubular cells, entering the interstitial fluid, and moving into the peritubular capillaries.
Materials that are secreted move in the opposite direction, from
the blood in the peritubular capillary to the tubular filtrate.
Both reabsorption and secretion occur where
throughout the renal tubule;
the majority of reabsorption occurs within
the proximal convoluted tubule.
Tubular reabsorption and tubular secretion differ in that __________.
tubular secretion adds materials to the tubular filtrate while tubular reabsorption removes materials from the tubular filtrate
Which of the following substances utilizes paracellular transport in order to cross the basolateral membrane of the tubule cell during the process of reabsorption?
potassium
filtrate formed at the renal corpuscle enters the
renal tubule at the pct where it is now referred to as tubular fluid
what is path of filtrate tubular flow
renal corpuscle to p.c.t.to nephron loop to d.c.t to collecting duct
reabsorption occurs as
materials are selectively moved out of the tubular fluid and return to the blood at the peritubular capillary
secretion occurs as
materials are moved out of the pertibular capillary into the tubular fluid
materials that are reabsorbed ultimately remain where
the blood supply
what eventually happens to the materials that are secreted
become components of urine
paracellular transport
crossing between the epithelial cells; such as potassium
transceullar transport
entering tubular cells at the luminal membrane and exiting cells at the basolateral membrane; such as sodium, glucose, water
Materials are selectively reabsorbed through either
passive or active transport processes.
the majority of sodium reabsorption occurs where
at the p.c.t.
approximately 65% of the cumulative h20 reabsorption happens where
at the p.c.t.
obligatory h20 reabsorption
approximately 65% of the cumulative h20 reabsorption happens where
glucose enters the tubular cells through ________ which allows glucose to move against its concentration gradient
sodium-glucose symport channels found at the luminal membrane
The majority of sodium reabsorption occurs at the proximal convoluted tubule. During this process, sodium enters the tubule cells at the __________ and exits the tubule cells at the __________.
luminal membrane by facilitated diffusion; basolateral membrane through the sodium potassium pumpCorrect
Glucose that is reabsorbed into tubular cells travels __________ its concentration gradient through sodium-glucose symport channels at the luminal membrane. Glucose in tubular cells exits the basolateral membrane into interstitial fluid through the process of __________.
against; facilitated diffusion
Materials are selectively reabsorbed through either
passive or active transport processes.
Uric acid is a nitrogenous waste produced by
peroxisomes as a result of nucleic acid metabolism.
Uric acid levels increase with
increased tissue breakdown and a high purine diet.
Uric acid is produced in
the liver, transported in the blood, and excreted by the kidneys.
Uric acid has limited solubility and high levels can result in
crystallization within the joints. This is termed goutand is considered a type of inflammatory arthritis.
Essentially all of the uric acid within the blood crosses
the filtration membrane and becomes part of the tubular filtrate.
Uric acid is almost entirely reabsorbed at the
proximal convoluted tubule through anion-exchange.
Approximately 10% of this reabsorbed uric acid gets secreted back into
the filtrate at the distal convoluted tubuleand is excreted in the urine.
At normal levels, uric acid partially acts as an
anti-oxidant in the body.
Hyperuricemia,
or high blood uric acid levels, may occur if the levels of uric acid rise (ex. when tissue breakdown is accelerated) or if the kidneys fail.
Many medications can affect both the reabsorption and secretion of uric acid within the renal tubule. is one such drug used to treat chronic gout by inhibiting the reabsorption of uric acid.
Probenecid®
Under normal conditions, the majority of uric acid reabsorption occurs at the __________.
proximal convoluted tubuleCorrect
Treatment with Probenecid®results in __________ levels of uric acid in the urine and __________ levels of uric acid in the blood.
increased; decreasedCorrect
The tubular filtrate in the nephron loop and blood within the vasa recta run parallelbut in
opposite directions.
This arrangement is referred to as the
countercurrent exchange system.
countercurrent exchange system. This design system together with urea recylcing is repsonsible for
establishing the interstitial fluid concentration gradient within the medulla.
The descending and ascending limbs of the nephron loop vary in
permeability.
The descending thin limb is
highly permeable to water and impermeable to salts
while the thick ascending limb is
impermeable to water and highly permeable to sodium.
Water moves out of tubular filtrate at the
descending limb due to osmotic pressure differences between the tubular filtrate and interstitial fluid. This causes the tubular filtrate to become more and more concentrated as it descends.
In contrast, the thick ascending limb is impermeable to
water but actively pumps salt out of the tubular filtrate. This causes the tubular filtrate to become more and more dilute as it ascends.
At the beginning of the nephron loop, the tubular filtrate is essentially
isotonic to the interstitial fluid in the cortex.
The countercurrent multiplier allows for
the tubular filtrate to become much more concentrated (hypertonic) as it descends deeper into the medullawhereas the tubular filtrate becomes hypotonic to the cortex as it ascends and exits the nephron loop.
the area of the medullary is an area of increasing ??
osmolarity
blood flow in the vasa recta runs how
opposite to the flow of the tubular fluid; rsulting in countercurrent exchange of materials between these two regions
the opposing flow encourages what
the movement of h20 out of the tubular fluid and into the blood in the descending limb while enhancing movement of h20 out of blood and into interstial fluid in ascending limb
the higher concentration of solutes in the medulla is largely influenced by
the high conentration of urea in the region
where does urea enter the tubular fluid
at the permeable thin segment of the ascending limb
where does urea leave the tubular fluid
reenters interstitial fluid at collecting ducts
The interstitial fluid within the medulla has a __________ osmolarity than the interstitial fluid within the cortex.
higher
The vasa recta is a specialized capillary that branches from the __________ arteriole. The blood flow in the vasa recta runs __________ to the flow of tubular filtrate within the nephron loop.
efferent; parallel but in the opposite direction
Hypertension affects approximately ____of the adult population in the U.S. and is classified into ‘primary hypertension’ and ‘secondary hypertension.’
20%
Primary hypertension
has no specific, single identifiable factor and is the most common cause of hypertension.
Secondary hypertension
can be attributed to a specific cause, such as chronic volume overload. For patients in which modified diet and exercise plans do not significantly improve hypertensive symptoms, diuretics may be prescribed.
Diuretics increase
urine output and decrease fluid volume by reversibly inhibiting Na+ reabsorption at specific sites of the nephronand increasing the excretion of both Na+ and water. This results in decreased blood volume and blood pressure, improving hypertension.
Diuretics work at
different sites on the nephron.
Loop diuretics
(ex. Furosemide, Bumetanide, and Torsemide) act at specific sites along the nephron loopand specifically inhibit the Na+/K+/2Cl- symport (NKCC2) found at the luminal membrane of the thick ascending loop, thereby preventing the reabsorption of sodium, chloride, and potassium.
Thiazides
(ex. Chlorothiazide and hydrochlorothiazide) act on the Na+/Cl- cotransporter at the distal convoluted tubule (DCT) and inhibit Na+ and water reabsorption in this region.
Individuals with Bartter syndrome have a defective gene coding for Na+/K+/2Cl- symport (NKCC2) that disables it from functioning. These individuals are expected to have __________ than normal blood potassium levels. This response is the __________ what is expected from individuals taking prescribed loop diuretics.
lower; same asCorrect
The nephron loop is responsible for approximately 25% of the reabsorption of sodium. Loop diuretics cause an overall __________ in the reabsorption of sodium in this region resulting in a(n) __________ in the osmolarity of the tubular filtrate.
decrease; increase
Decreased Na+ and water reaborption due to the use of loop diuretics and thiazides __________ the concentration gradient of the interstitial fluid, thereby __________ the osmotic force at the collecting tubule and duct.
lowers; reducing
The peritubular capillaries are separated from the nephron by
the interstitial fluid, thus movement of substances between the nephron and blood is always through the interstitial fluid.
The processes of reabsorption and secretion occur at the
distal convoluted tubule, collecting tubule, and collecting ductand regulate the composition of both blood and urine.
the distal convoluted tubule, collecting tubule and collecting duct regions of the nephron in particular are susceptible to
hormonal regulation of ion and water transport.
Hormones that regulate both sodium and water include
aldosterone and antidiuretic hormone (ADH).