First Pass Metabolism Flashcards
What vein absorbs oral/rectal drugs
Hepatic portal vein
Where are the drugs taken to when absorbed
The liver
What is the function of the liver
Prevents toxins from being absorbed from GI tract
Protects systemic circulation
What does the liver act as
A poison filter
How does the liver detoxifies mechanisms
Defoliates and metabolises drugs
What is first pass metabolism
Process where drug is significantly metabolised before it reaches systemic circulation
What is the second pass/other pass metabolism
The drug passing through the liver from systemic circulation via hepatic artery
How does the second pass metabolism affect the drug concentration
Reduces the drug concentration
What happens to high hepatic extraction drugs
Large portion is removed before it enters systemic circulation from liver
Example of high hepatic extraction drug
Glycerol trinate
