Distribution Flashcards
What can bind to a drug
Plasma protein
Example of plasma protein
Albuimin
What happens to the bound drug
It’s inactive
Why is the bound drug inactive
Drug protein complex can’t pass across cell membrane
What does the bound drug act as
It acts as a backup as the drug can detach from the protein and replenish the amount in the blood
In what case is this beneficial and how(low protein plasma patient)
If the patient has low levels of plasma protein more of the drug will be free in the blood
Why would a patient have low plasma protein
Malnutrition or liver disease
How can changes in the levels of protein bound be important
It is important for drugs with narrow therapeutic range
Example of drugs with narrow therapeutic range
Warfarin/ phentoyin
For the unbound drug to work, it must be
Transferred across a lipid
What can be a negative effect of free drug in blood due to low plasma
Leads to toxicity
