Enzyme Induction Flashcards
What is enzyme induction
Process in which a drug increases the production of enzymes in the body
Where does enzyme induction occur
Liver
What does enzyme induction affect
It affects the rate drugs are metabolised [increased or decreased]
What in relation to chronic drug administration is enzyme induction responsible for
Tolerance
What is the metabolism of drugs in really old and young people like
Reduced metabolism of drugs
What causes the reduced metabolism of drugs in old and young people
Hepatic microsomes enzyme activity
What affects the rate of drug metabolism
Racial or genetic factors
What are the 2 types of acetytlators
Fast acetylator and Slow acetylator
What is acetylator
How quick or slow a persons body a process certain drugs through acetylation
Key features of fast acetylator
-metabolise drugs quickly
-higher dose of same medication needed to feel the same as slow acetylators
-drug leaves their system faster
Key features of slow acetylator
-metabolise drugs slower
-lower dosage of drug required
-drug stays in their system for longer which may lead to side effects
Explain the metabolising of hydralazine
-what it is
-how it works
In relation to aceetylation
Hydralazine is a drug that owners blood pressure
-works with enzyme acetyl- coenzyme A
-broken down into different drug when metabolised
-slow acetylators break down the drug slower and require lower dosage
-fast acetylators break it down faster and need a higher dosage as the drug leaves their body
