First Aid-Exotoxins

Question 1

Toxin that produces pseudomembranes in throat and sever lymphadenopathy.
Inactivates EF-2.

Answer 1

Diptheria toxin (corynebacerium diptheriae)

Question 2

Exotoxin Aa

Answer 2

Inactivates EF-2

Pseudomonas A.

Question 3

Shiga Toxin

Answer 3

Inactivates 60 s (removes adenine from tRNA)
shigella– produces dysentery
HUS

Question 4

EHEC (O157:H7)

Answer 4

shiga like toxin.
Inactivates 60s (removes adenine from tRNA)
HUS, bloody diarrhea

Question 5

What are the three symptoms of HUS

Answer 5

1. hemolytic anemia
2. thrombocytopenia
3. acute renal failure

Question 6

What are the 2 toxins of ETEC? and symptoms?

Answer 6

1. heat labile toxin
2. heat stable toxin
   ETEC produces watery diarrhea

Question 7

How does the heat labile toxin from the heat stable toxin?

Answer 7

heat labile–increases cAMP

heat stable–increases cGMP

Question 8

Anthrax (bacilla anthracis)

Answer 8

1. Edema Factor–increases cAMP
2. Lethal factor
   3.

Question 9

cholera toxin

Answer 9

Permanently activates Gs and increases cAMP. Rice water stools.

Question 10

Pertussis toxin

Answer 10

increase cAMP by disabling Gi

(impairs phagocytosis of microbe)?

Question 11

Tetanospasmin results in what symptoms?

Answer 11

Clostridium tetani (tetanus toxin)..inhibits release of GABA and glycine by cleaving SNARE proteins.
results in sardonic smile and lock jaw and a spastic paralysis.

Question 12

Flaccid Paralysis.

Answer 12

Botulinum toxin, prevents the release of ACh by cleaving SNARE proteins.