First Aid Flashcards
Pulse pressure is inversely proportional to; what is it proportional to
Compliance; SV
What causes increases in pulse pressure
Hyperthyroidism, aortic regurgitation, aortic stiffening, obstructive sleep apnea, exercise
What causes decreased pulse pressure
Aortic stenosis, cardiogenic shock, cardiac tamponade, heart failure
What causes increased CO for early exercise? Late?
Increases in HR and SV; as SV plateaus only HR can increase
Which phase is shortened with increased heart rate
Diastole -> decreased filling -> decreased CO -> v-tac
What increases SV
Increased contractility, increased preload, decreased afterload
Contractility increases with
- Catecholamine stimulation via β1 (causes more Ca to enter cell because of phosph. Ca channels and phosph. phospholambin means more Ca stored in SR)
- Increased intracellular Ca
- Decreased extracellular Na
- Digitalis
Contractility decreases with
- β1 blockade (decreased cAMP)
- HF with systolic dysfunction
- acidosis
- hypoxia/hypercapnia
- Non-dihydropyridine Ca channel blockers
What causes increases in myocardial O2 demand
Increased contractility
Increased afterload
Increased heart rate
Increased diameter of ventricle (more stress)
What does nitroglycerin dilate
Veins
What do venous vasodilators do
Decrease preload
What approximates preload
EDV (general measure of blood in circulation)
What do arterial vasodilators do
Decrease afterload
What do ACE inibitors and ARBs do
Decrease preload and afterload
What does a narcotics overdose do for the heart
Decrease inotropy
The first side of the pressure volume loop represents what phase
Isovolumetric contraction (both valves are closed)
Where is the first heart sound heart in pressure volume loop
Bottom right corner
What is the top curve in the pressure volume loop
Systolic ejection after aortic valve opens
What is the left side of the pressure volume loop
Isovolumetric relaxation
Where is the second heart sound on pressure volume loops
Top left corner
Where is the this heart sound on the pressure volume loop
Bottom left corner to the left of midline