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blood bank > Finals - Component prep, therapy > Flashcards

Finals - Component prep, therapy Flashcards

1
Q

which of the ff is not a sterilization method used for blood?

a. Gamma irradiation
b. UV light exposure
c. Ethylene oxide
d. Electron beam

A

B

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2
Q

___ describe the characteristics of an ideal blood container (8)

A 
1 Free from pyrogens, 
2 Un-colored and transparent, 
3 Identified by a lot number
4 not past expiration date,  
5 should withstand sterilization methods
6 allow O2 and CO2 exchange
7 prevents water evaporation
8 may be latex free
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3
Q

(T/F) Blood bags with in-line filter can remove

leukocytes from whole blood and RBCs

A

true

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4
Q

____ are fever causing agent

A

pyrogens

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5
Q

*(T/F) Anticoagulant containing citrate can cause Ca2+ deficiencies in patients

A

true

coz citrate bind Ca2+

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6
Q

which of the ff anticoagulants are more commonly used?

a. Acid-Citrate-Dextrose (ACD)
b. Citrate-Phosphate-Dextrose (CPD)
c. Citrate-Phosphate-Dextrose-Dextrose (CP2D)
d. Citrate-Phosphate-Dextrose-Adenine (CPDA-1

A

C and D

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7
Q

(T/F) adenine component in Anticoagulant solutions decreases its shelf life

A

false

increases shelf life

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8
Q

____ volume of anticoagulant used for every 450 and 560 ml of blood

A 
500ml = 70 ml anticoag
450ml = 63 ml anticoag
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9
Q

____ these solutions are added to blood bags for the survival of RBCs and increases exp date

A

additive solutions (AS)

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10
Q

___ the enzyme maintained by AS during the storage of blood

A

2,3-DPG

clarify this

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11
Q

____ the max amount of blood to be collected

A

10.5 mg blood/ Kg

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12
Q

____ for which transfusion therapy can a unit of blood be used for? (4)

A

1 RBCs
2 Platelets
3 Fresh Frozen Plasma (FFP)
4 Cryoprecipitate

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13
Q

which of the ff is false?

a. platelets rich plasma can be extracted from slow spinning of whole blood
b. FFP must be frozen w/in 6 hours after a hard sprin
c. Cryosuperprecipt is extracted before FFP is frozen
d. PRBC can be separated from both slow and hard spin

A

C

Cryo is extracted after slow-hard spin of thawed FFP

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14
Q

(T/F) usually whole blood is used in transfusion

A

false

WB is separated into components, allow transfusion therapy to be
targeted

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15
Q

(T/F) platelets are stored in RT

A

true

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16
Q

the volume used for the transfusion for neonates

a. 5 ml
b. 20- 25 ml
c. 30 ml
d. 10-25 mL

A

D

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17
Q

___ the type of blood bag used to store blood for neonatal transfusion

A

quad pack, pedi-packs

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18
Q

(T/F) when blood for neonate transfusion is done in sterile conditions (closed systems), the expiration date of the sample decreases

A

false

same as in original bag

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19
Q

which of the ff anticoagulants are more commonly used for NEONATES?

a. Acid-Citrate-Dextrose (ACD)
b. Citrate-Phosphate-Dextrose (CPD)
c. Citrate-Phosphate-Dextrose-Dextrose (CP2D)
d. Citrate-Phosphate-Dextrose-Adenine (CPDA-1)

A

D

esp for large volumes

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20
Q

which of the ff is NOT qualified for transfusion of aliquot/split units of blood?

a. Patients with severe chronic anemia
b. Overt heart failure
c. Severe renal failure
d. neonates

A

all are candidates :)

21
Q

*____ the purpose of irradiation

A

Prevent the proliferation of T-lymphocytes = stop t-GVHD

22
Q

_____ the phenomena where donor T cells attacks the recepients tissues

A

t-GVHD = transfusion-associated-graw versus host disease

23
Q

___ list who are at risk for t-GVHD (5)

A

Immunocompromised patients
Bone marrow or stem cell transplant
Intrauterine transfusion of at risk fetuses
Patients who received blood from relatives
Patients receiving HLA-matched platelets

24
Q

(T/F) the minimum dose of dose of gamma irradiation is > 5000cGY

A

false

25Gy (2500cGY)
– Cesium 137
– Cobalt 60

25
Q

____ exp date of RBCS from the time of irradiation

A

28 days after

26
Q

____ Absolute WBC count in the unit (Leukocyte reduced RBCs)

A
27
Q

which pro inflammatory agents are prevented from being released by WBC in storage after sample is irradiated/ leukocyte reduced?

a. IL-1
b. IL-6
c. C3a
d. C5a

A

all of the above :)

28
Q

(T/F) WBCs can also be removed at the bedside before transfusion

A

true

Reactions due to anti leukocyte antibodies
(present in the patient’s plasma) are prevented

29
Q

(T/F) in the bedside removal of WBCs, biologic response modifiers and pro inflammatory agents are removed

A

false

30
Q

___ list the adverse reactions WBCs are associated with (5)

A

Febrile-non-hemoly,c transfusion reactions,
Transfusion-related acute lung injury
transmission of EBV and CMV and HTLV

31
Q

____ Frozen Deglycerolized RBCs

A

Method of freezing RBCs with glycerol

can be stored up to 10 yrs

32
Q

(T/F) RBCs should be frozen with glycerol within 2 weeks of collection if CPD or CPDA-1 is used

A

first part False

stored w/in 6 days

AS-1, AS-3 and AS-5 – up to 42 days

33
Q

(T/F) freezing RBC with glycerol prevents water from leaving the cell as ice is formed outside

A

true

uses 40% glycerol, stored at -80C

34
Q

____ Deglycerolized RBCs expiration time

A

after 24hrs of thawing

35
Q

which of the ff is not included: deglycerolized RBC products are free of

a. additives
b. WBCs
c. Platelets
d. Plasma

A

A

36
Q

(T/F) platelets can be extracted from whole blood by either slow or hard speed spinning

A

true

see lec 9 notes pg 43 onwards

37
Q

(T/F) a single whole blood should contain a therapeutic dose of 5 x 10^10 platelets

A

first part false

dose is from a pool of 5-6 RDP

38
Q

____ the increase in the patient’s platelet count after a dose of platelet therapy

A

50,000/μL

39
Q

____ when Platelet fraction is collected from a single donor (SDP) and remaining
components are returned to donor

A

apharesis platelet

40
Q

(T/F) SDP contains a minimum of 3 x 10^11 platelets for one therapeutic dose

A

true

41
Q

(T/F) irradiation of platelets affects its shelf life

A

false

42
Q

which of the ff is not true about FFP?

a. obtained from SDP
b. contains FVIII
c. volume must be 500 ml
d. frozen w/in 6-8 hrs depending on anticoagulant

A

C

Volume 150 – 250 mL

43
Q

(T/F) FFP from SDP is given to emergency patients requiring volume

A

true

44
Q

which of the ff is not true about FFP?

a. stored at −18⁰C or colder
b. Expira,on – 1 year from date of collection
c. PF24 & FFP – thawed at 37⁰C
d. can be thawed in microwave

A

all is true :)

45
Q

(T/F)>24 hrs – converted to “thawed plasma” and can

be used 3-5 days

A

true

46
Q

___ are plasma that are deficient in FVIII/fibrinogen; PPP and used as volume expanders

A

Plasma and Liquid Plasma

47
Q

___ plasma containing pools of up to 2500 units of ABO type-specific, triton X-100 and inactivates lipid-envelope virus e.g.,
HIV and HBV

A

Solvent Detergent Plasma (S/D plasma)

48
Q

____ contains 80 units antihemophilic factor, cold precipt of FVIII, obtained from single whole blood unit collected in CPD or CPDA-1

A

Cryoprecipitate

49
Q

which does not apply to cryo?

a. Expiration – 1 year if stored at ≥ −18⁰C
b. Transfused within 6 hrs of thawing
c. Adult dose – pool of 20 units
d. transfused w/in 4 hrs awer pooling

A

C

pool of 8-10 units

blood bank (10 decks)

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