exam 2 - other blood group systems Flashcards
(T/F) antigens are part of a gene sequence that codes only for the structure of the antigen
false
some genes code for enzymes that form the ag
(T/F) transfusion recipients can get a matched ABO and Rh but are not likely to receive identical cells in other blood group system
true
_____ identifies a blood group /antigen in a blood group
alloantibody
which of the ff blood group system contains the least amount of polymorphism? (clarify this)
a. Lw
b. MNS
c. Rh
d. Kell
A
(T/F) DNA analysis can detect polymorphisms/ variants that can be classified into a blood group
false
MUST be defined by an alloantibody
(T/F) type 1 single pass antigens have an intracellular C-terminal structure
true
Type 2 single pass have intracellular N-terminal
which of the ff is not a carbohydrate-type blood group?
a. ABO
b. Lewis
c. P
d. duffy
D
which of the ff is false about Secretors?
a. FUT2 secretor gene produces fucosyltransferase like the H gene
b. Secretors have ABH substance in body secretions and in plasma
c. Se fucosyltransferase acts on Type 2 chains
d. onlly 20% of the population are non-secretors
C
acts on type 1 chains (soluble precursor)
which of the ff is the gene that codes for fucosyltransferase involved in the Lewis system?
a. FUT4
b. FUT3
c. FUT2
d. FUT1
B
FUT3 = Le FUT2 = Se
(T/F) Lewis antigen is formed in plasma and subsequently adsorbed onto RBCs
true
which of the ff is false about the Lewis system?
a. Le gene is linked to Se and H genes
b. Le gene codes for enzymes that form both Le(a) and Le(b) antigens
c. only the Le(b) antigen is adsorbed in RBCs
d. Le(b) is formed thru interactions of FUT3 and FUT2 genes
B
Le gene alone = Le(a)
Le gene + Se gene = Le(b)
(T/F) type 2 chains are found in cell surface membranes
true
which of the ff is a non secretor?
a. Le (a+b-)
b. Le (a-b-)
c. Le (a+b+)
d. Le (a-b+)
A
B can also be a non secretor (LeSe but Le gene may be mutated)
(T/F) an Le(a-b+) phenotype means that only Le(b) is present in both RBCs and in plasma
false
Le(a) can also present but is not as easily absorbed into RBCs so only Le(b) is detected
(T/F) the Le gene codes for an enzyme that forms the Le(b) antigen
true
(T/F) the Le(a+b-) phenotype is most common among whites, blacks and japanese
false
Le(a-b+) is most common,
Le(a+b-) is a non secretor (found in minority)
Lewis antibodies are:
a. IgG
b. IgM
B
cold reactive
which of the ff is not true about Lewis ab?
a. are only found in Le(a-b-) phenotype
b. anti-Le(a) may react and bind compl at 37C
c. are never IgG
d. Anti-Le(a) is stronger and more common that anti-Le(b)
C
some can be IgG
which of the ff is true about P blood group?
a. D-galactose is the immunodominant sugar
b. does not add L-fucose
c. P antigens are formed on type 1 chains
d. P1 antigen are found on other blood cells
C
formed in type 2 chains
which phenotype will most likely react with anti-P?
a. P1 only
b. P2 only
c. P1 and P2
d. p (null)
C
coz P1 has P1 and P precursor
P2 = P1 neg but still has P precursor
(T/F) the P2 phenotype reacts with Anti-P1 and not with Anti-P
false
coz P2 = P1 neg + P precursor
P2 reacts with anti-P only
which of the ff is not true?
a. Anti- PP1Pk is reactive over broad thermal range
b. P1k and P2k phenotypes are rare
c. anti-P1 is a rare, severe reacting ab
d. Anti-P1 is rarely IgG
C
it is a common benign ab
(T/F) ab directed againts P and Pk ag are associated w/ higher abortion rate in women with p or P1k or P2k phenotype
true
which of the ff is false?
a. both I and i ag are low incidence ag
b. the i ag is present mostly at birth or cord blood
c. i antigen is a branched precursor for ABH antigens
d. I and i are not antithetical
A
are high incidence
so Ab against them are rare