Final - Vanrign Pt 2 Flashcards
2 main pathways of action for cocaine
Increase in catecholamines - by being an antagonist of DAT
and
decrease Na+ transport
what drugs can be used for narcolepsy
amphetamine
methylphenidate
armodafinil/modafinil
Sodium Oxybate
which stimulant inhibits BOTH DAT and NET
methylphenidate
which stimulant is a prodrug of amphetamine and modulates dopamine transport
lisdexamphetamine
how do drugs like phentermine for weight loss work?
stimulate release of NE and DA in lateral hippocampus aka feeding center of brain
Nicotine:
full agonist, or partial agonist, or antagonist at nicotinic ach receptors?
full agonist
Nicotinic ach receptors are what kind of structure?
pentameric
T or F: Nicotine is degraded by Acetylcholinesterase just like Ach
False - nicotine is not and thus has a long half life than Ach
what meds can be used for treating nicotine addiction — specifically agonist meds
nicotine patch/gum/e-cig
what meds can be used for treating nicotine addiction — specifically partial agonist meds
varenicline
what meds can be used for treating nicotine addiction — specifically antagonist meds
bupropion
methylxanthines (like caffeine) are ______ to adenosine receptors
antagonists
how does cocaine affect the dopamine transporter
it is an antagonist to it in the nucleus accumbens
same as methylphenidate
how does meth/ecstasy/bath salts affect DA
it pushes DA out from vesicles, changes gradient, whihc forces transporter to work in the reverse
is cocaine or meth a bigger structure?
cocaine - why only an antagonist and doesn’t go inside the cell like meth does to affect vesicle release of DA
Nicotine is inhibitory or excitatory
excitatory
amphetamines are contraindicated with antidepressants???
to vanrijn yes because amphetamines are MAOIs too and that is not ok with antidepressants (but who knows if actually applicable)
crack or cocaine gets smoked and why?
crack does because you add ammonia to make a free base = lower melting temp when free base
bath salt is known as a synthetic ______
cathinone
ADEs of Cathinone use (aka bath salts)
hyperthermia
paranoid delusion
cardiac arrest
anxiety/violence
PK of alcohol:
peaks in ______ minutes
30 - 90