Exam 3 - Rochet (CNS/MS Drugs) Flashcards
3 main parts of brain
hindbrain
midgrain
forebrain
main parts of hindbrain
medulla
pons, cerebellum
main parts of midbrain
substantia nigra (SN)
main parts of forebrain
cerebral cortex
basal ganglia (minus SN)
limbic system
diencephalon
what makes up limbic system
hippocampus
amygdala
what makes up basal ganglia
striatum
globus pallidus
subthalamic nucleus
what makes up the diencephalon
thalamus
hypothalamus
is it in the hindbrain, midbrain, forebrain?
medulla
hindbrain
is it in the hindbrain, midbrain, forebrain?
substantia nigra
midbrain
is it in the hindbrain, midbrain, forebrain?
pons, cerebellum
hindbrain
is it in the hindbrain, midbrain, forebrain?
cerebral cortex
forebrain
is it in the hindbrain, midbrain, forebrain?
basal ganglia
forebrain
is it in the hindbrain, midbrain, forebrain?
limbic system
forebrain
is it in the hindbrain, midbrain, forebrain?
diencephalon
forebrain
is it in the hindbrain, midbrain, forebrain?
hippocampus
in limbic system — therefore in FOREBRAIN
is it in the hindbrain, midbrain, forebrain?
amygdala
in limbic system — therefore in FOREBRAIN
is it in the hindbrain, midbrain, forebrain?
hypothalamus
in diencephalon — therefore in FOREBRAIN
is it in the hindbrain, midbrain, forebrain?
thalamus
in diencephalon — therefore in FOREBRAIN
what is the overall function of medulla
autonomic functions
what is overall function of pons
a “bridge”
relays signal from forebrain to cerebellum
Pons: relays signal from ______ to _______
from forebrain to cerebellum
main function of cerebellum
“little brain”
governs motor coordination for producing SMOOTH movements
Medulla does conscious or non-conscious actions?
NON-conscious/autonomice
reflexes, respiration, cardiac function etc…
_________ undergoes neurodegeneration in spinocerebellar ataxias
cerebellum
Substantia Nigra: Pars Compacta
provides _____ to basal ganglia (supplies _______ to the ______
provides INPUT
supplies DOPAMINE to STRIATUM
what are the two parts of substantia nigra
pars COMPACTA
or pars RETICULATA
Substantia Nigra: Pars Reticulata
has ______ function
relays signal from _________ to ______
OUTPUT function
from basal ganglia; to thalamus
Pars Compacta or Pars Reticulata?
has input function
compacta
Pars Compacta or Pars Reticulata?
has output function
reticulata
Pars Compacta or Pars Reticulata?
provides signal to basal ganglia
compacta
Pars Compacta or Pars Reticulata?
provides signal to thalamus
reticulata
Pars Compacta or Pars Reticulata?
supplies dopamine to striatum
compacta
Pars Compacta or Pars Reticulata?
involved with voluntary motor control
compacta (b/c dopamine)
main function of cortex
processing/interpreting information (executive function)
other name for cortex
cerebrum
main role of basal ganglia
voluntary motor control
some cognitive functions
main role of limbic system
emotions and memory
emotions - amygdala; memory - hippocampus
what is the role of amygdala
emotions
what is the role of hippocampus
memory
main role of diencephalon
relay station to AND from cortex
regulating internal homeostasis, emotions, hormonal control, and direct regulation
(relaying - thalamus; hypothalamus does the rest (aka lots of regulation)
main role of thalamus
relay station to AND from cortex
main role of hypothalamus
regulating internal homeostasis, emotions, hormonal control, and direct regulation
Decisions are made in “______________” about how to interpret and act on the incoming sensory information
cortico-thalamic loops
Schizophrenia is considered a disease of the _______
frontal cortex
damage to the cortex can affect what things?
movement, speech, personality
T or F: when there is damage to the cortex, drugs are not typically available to treat these deficiencies
True!!
exception is Schizophrenia tho
Afferent or Efferent Neuron Tracts?
transmit signals from cortex to periphery
efferent
Afferent or Efferent Neuron Tracts?
transmit signals from periphery to cortex
afferent
brain is surrounded by layers of membranes collectively known as the ______
meninges
3 main layes of meninges
dura
arachnoid
pia
Dura, Arachnoid, Pia layer of meninges?
us closest to bone
dura
dura = hard next to bone
Dura, Arachnoid, Pia layer of meninges?
is closest to brain
pia
Dura, Arachnoid, Pia layer of meninges?
is the middle layer
arachnoid
Dura, Arachnoid, Pia layer of meninges?
is the outer layer
dura
Dura, Arachnoid, Pia layer of meninges?
is the inner layer
pia
what fills the space b/w arachnoid and pia layers?
CSF - cerebrospinal fluid
blood enters brain via the ________
carotid artery
once carotid artery enters the brain… it branches into what things?
4 arteries total…
opthalmic artery;
anterior, middle, and posterior cerebral arteries
CNS consists of ______ and _____ cells
neurons;
glial cells
which is more abundant?
neurons or glial cells
glial cells
3 main glial cells
astrocytes
Oligodendrocytes
Microglia
Role of Astrocytes
provide neurons w/ _________ & _______
remove excess __________
support the _________
provide growth factors and anti-oxidants
remove excess GLUTAMATE
support BLOOD BRAIN BARRIER
Role of Oligodendrocytes
produce myelin sheath that insulates axons
Role of Microglia
Clear debris!!
also provide growth factors
(if too many microglia => inflammation)
why is it good astrocytes remove excess glutamate
too much glutamate can damage neurons
Astrocytes, Oligodendrocytes, or Microglia?
remove debris
Microglia
Astrocytes, Oligodendrocytes, or Microglia?
remove excess glutamate
astrocytes
Astrocytes, Oligodendrocytes, or Microglia?
make myelin sheath for axon insulation
oligodendrocytes
Astrocytes, Oligodendrocytes, or Microglia?
support blood brain barrier
astrocytes
Astrocytes, Oligodendrocytes, or Microglia?
provide growth factors
astrocytes (mainly)
also microglia
Astrocytes, Oligodendrocytes, or Microglia?
provide anti-oxidants
astroyctes
Blood Brain Barrier:
stabilized by ________ in the ______ cell layer of blood vessels in the brain
tight junctions
in endothelial cell layer
Neurotransmission is triggered by ______ of the neuron
electrical depolarization (shocking…)
Neurotransmission occurs when a influx of ______ changes polarity of membrane
Na+ ions…