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Pathology II > Final Study Guide > Flashcards

Final Study Guide Flashcards

1
Q

What disease is associated with a mutation in Type I collagen?

A

Osteogenesis imperfecta

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2
Q

Give a potential diagnosis based on this X-ray and histological slide:

X-ray: multilocular radiolucency crossing midline of mandible, root resorption (third molars not in yet so its a kid)

Histology: multi-nucleated giant cells (AKA chocolate chip)

A

Central giant cell granuloma

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3
Q

All of the following describe McCune Albright syndrome except:

a) cafe au lait pigmentation
b) multiple endocrine lesions
c) polyostotic disease of fibrous dysplasia
d) hypofunction of cells involved in the tissue

A

d) hypofunction of cells involved in the tissue

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4
Q

What is a potential diagnosis for a patient with intestinal polyps?

A

Gardner syndrome

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5
Q

Immunohistochemistry test for multiple myeloma would likely present what?

A

Monoclonal light chain

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6
Q

What disease is associated with multiple myeloma?

A

Multiple myeloma

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7
Q

What is the gene mutation for cherubim?

A

SH3P2

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8
Q

What would you expect to see under a microscope for langerhans cell histiocytosis?

A

Birbeck granules

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9
Q

What disease is commonly associated with supernumerary teeth?

A

Gardner’s syndrome

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10
Q

Differential diagnosis for:

X-ray:
-posterior mandible
-large, well-circumscribed radiolucency
-involving the roots
-tooth “Floating in air”

A

Langerhan’s cell histiocytosis

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11
Q

Patient is 70 years old and presents with this radiograph:

X-ray: punched out radiolucencies all over skull

What is your diagnosis?

A

Multiple myeloma

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12
Q

Upon a biopsy of a lesion, what are you expecting to find for the histology of a focal osteoporotic defect?

A

Hematopoietic bone marrow defect

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13
Q

Patient presents with this lesion that has not expanded in ten years, pulp testing reports vital, what is your diagnosis?

X-ray:
-radiopacity
-associated with apex of molar & premolars
-unilocular

A

Idiopathic osteosclerosis

(increased radiopacity, non-expansile, mandibular molar-premolar area, vital teeth)

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14
Q

List three possible differential diagnosis for this X-ray:

A
  1. ameloblastoma (conventional)
  2. multiple OKCs (nevoid basal cell syndrome)
  3. central giant cell granuloma
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15
Q

Radiograph of a unilocular radiolucency- what can this NOT be?

A

Botryoid Odontogenc cyst

Mr. Botryoid likes grapes

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16
Q

Radiograph of odontoma- what cyst is most commonly associated with this?

A

Calcifying odontogenic cyst (gorlin cyst)

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17
Q

Histology presents a corrugated surface, prominent, palisaded, hyper chromatic basal layer- what is most likely the radiographic presentation?

A

Multilocular radiolucency (OKC)

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18
Q

What is the reason for recurrence of OKC?

A

Daughter/satellite cysts

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19
Q

A 50 year old male comes in with this radiograph (huge multilocular mass in posterior mandible). What is NOT in your differential diagnosis?

A

Ameloblastic fibroma - because this is a kiddie tumor

20
Q

Which of the following will you NOT see with Nevoid Basal cell carcinoma syndrome? (Gorlin syndrome?

A

Multiple ameloblastomas

(you willl see: bifid ribs, multiple OKCs, nervous system neoplasms)

21
Q

Histology shows ghost cells, what is this?

A

Calcifying odontogenic cyst

(these ghost cells may be areas where calcification may occur)

22
Q

Patient presents with VITAL teeth and a radioLUCENCY that scallops the border of the roots. On biopsy the surgeon reports an empty cavity. The patient reports having a sports injury in the area. Diagnosis?

A

Traumatic bone cyst

23
Q

What presents with normal hematopoietic bone marrow histology?

A

Osteoporotic bone defect

24
Q

Histology shows REVERSE POLARITY of basal cell nuclei, NUCLEAR HYPERCHROMATISM, NUCLEAR PALISADING, and SUBNUCLEAR VACUOLATION. What is is?

A

Unicystic ameloblastoma

25
Q

Patient presents with a lesion characterized by whirling of the epithelium and pseudo-ducts. What is it?

A

Adenomatoid odontogenic tumor

-WHIRLING OF EPITHELIUM
-PSUEDO DUCTS

26
Q

What can present as a multilocular radiolucency?

A

Botryoid odontogenic cyst

27
Q

Which of the following is MOST AGGRESSIVE?

a) ameloblastic fibroma
b) complex odontoma
c) odontogenic myxoma
d) compound odontoma

A

c) Odontogenic myxoma

28
Q

What is LEAST likely to be a multilocular radiolucency?

A

Periapical cyst

29
Q

Histology shows PINK, POLYGONAL, POLYHEDRAL epithelial cells with calcifications. What is this?

A

Calcifying epithelial odontogenic tumor

30
Q

Histology shows amyloid and Liesegang ring calcifications? What is it?

A

Calcifying epithelial odontogenic tumor

31
Q

A biopsy was done on a radiopaque lesion. Histology shows that the lesion came out whole. What is it?

A

Cementoblastoma

32
Q

Radiograph showing a radiopaque mass in the posterior mandible, not resembling teeth. What is it?

A

Complex odontoma

33
Q

Patient presents with a NON-VITAL tooth and RADIOPACITY associated with the apex of the root. What is this?

A

Condensing osteitis

34
Q

What presents with multifocal radiopacities?

A

Gardner syndrome

35
Q

Picture of brown-blue teeth. Patient presents with multiple bone fractures & blue sclera, what is this?

A

Osteogenesis imperfecta

36
Q

What has a cotton wool radiographic appearance?

A

Paget disease of bone

37
Q

What is a developmental form of a benign fibre-osseous lesion?

A
  1. Fibrous dysplasia
  2. osseous dysplasia
  3. ossifying fibroma
38
Q

Which form of fibrous dysplasia involves cafe au lait pigmentation, endocrinopathy and craniofacial dysplasia?

A

Mccune Albright syndrome

  1. fibrous dysplasia
  2. cafe au lait
  3. endocrinopathy
  4. craniofacial dysplasia
39
Q

Patient presents with a fibrous lesion, Histology reveals Chinese-like characters, what is it?

A

Fibrous dysplasia

40
Q

Patient presents with radiopacities associated with the apex of several anterior mandibular teeth. The findings is incidental, What is it?

A

Peri-apical cemento-osseous dysplasia

41
Q

After extraction of a mandibular molar, a radiograph shows a radiopaque lesion at the extraction site. What is it?

A

Focal cemento-osseous dysplasia

42
Q

Diffuse radiopacities throughout the maxilla and mandible, what is it>

A

Florid cemento-osseous dysplasia

43
Q

A lesion was biopsied and came out in one piece, What is it?

A

Cemento-ossifying fibroma

44
Q

Patient presents with histology of extravasated RBCs, hemosideren, and multinucleated giant cells. Blood tests revealed an increased in parathyroid hormone, what is this?

A

Brown tumor

(central giant cell granuloma but hyperparathyroidism = brown tumor)

45
Q

What is the chronic focal form of langerhans cell histiocytosis?

A

Eosinophilic granuloma

46
Q

Localized, symmetrical widening of the PDL space is the ominous sign of what?

A

Osteosarcoma

Pathology II (17 decks)

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