Final Study Guide Flashcards
(47 cards)
What disease is associated with a mutation in Type I collagen?
Osteogenesis imperfecta
Give a potential diagnosis based on this X-ray and histological slide:
X-ray: multilocular radiolucency crossing midline of mandible, root resorption (third molars not in yet so its a kid)
Histology: multi-nucleated giant cells (AKA chocolate chip)
Central giant cell granuloma
All of the following describe McCune Albright syndrome except:
a) cafe au lait pigmentation
b) multiple endocrine lesions
c) polyostotic disease of fibrous dysplasia
d) hypofunction of cells involved in the tissue
d) hypofunction of cells involved in the tissue
What is a potential diagnosis for a patient with intestinal polyps?
Gardner syndrome
Immunohistochemistry test for multiple myeloma would likely present what?
Monoclonal light chain
What disease is associated with multiple myeloma?
Multiple myeloma
What is the gene mutation for cherubim?
SH3P2
What would you expect to see under a microscope for langerhans cell histiocytosis?
Birbeck granules
What disease is commonly associated with supernumerary teeth?
Gardner’s syndrome
Differential diagnosis for:
X-ray:
-posterior mandible
-large, well-circumscribed radiolucency
-involving the roots
-tooth “Floating in air”
Langerhan’s cell histiocytosis
Patient is 70 years old and presents with this radiograph:
X-ray: punched out radiolucencies all over skull
What is your diagnosis?
Multiple myeloma
Upon a biopsy of a lesion, what are you expecting to find for the histology of a focal osteoporotic defect?
Hematopoietic bone marrow defect
Patient presents with this lesion that has not expanded in ten years, pulp testing reports vital, what is your diagnosis?
X-ray:
-radiopacity
-associated with apex of molar & premolars
-unilocular
Idiopathic osteosclerosis
(increased radiopacity, non-expansile, mandibular molar-premolar area, vital teeth)
List three possible differential diagnosis for this X-ray:
- ameloblastoma (conventional)
- multiple OKCs (nevoid basal cell syndrome)
- central giant cell granuloma
Radiograph of a unilocular radiolucency- what can this NOT be?
Botryoid Odontogenc cyst
Mr. Botryoid likes grapes
Radiograph of odontoma- what cyst is most commonly associated with this?
Calcifying odontogenic cyst (gorlin cyst)
Histology presents a corrugated surface, prominent, palisaded, hyper chromatic basal layer- what is most likely the radiographic presentation?
Multilocular radiolucency (OKC)
What is the reason for recurrence of OKC?
Daughter/satellite cysts
A 50 year old male comes in with this radiograph (huge multilocular mass in posterior mandible). What is NOT in your differential diagnosis?
Ameloblastic fibroma - because this is a kiddie tumor
Which of the following will you NOT see with Nevoid Basal cell carcinoma syndrome? (Gorlin syndrome?
Multiple ameloblastomas
(you willl see: bifid ribs, multiple OKCs, nervous system neoplasms)
Histology shows ghost cells, what is this?
Calcifying odontogenic cyst
(these ghost cells may be areas where calcification may occur)
Patient presents with VITAL teeth and a radioLUCENCY that scallops the border of the roots. On biopsy the surgeon reports an empty cavity. The patient reports having a sports injury in the area. Diagnosis?
Traumatic bone cyst
What presents with normal hematopoietic bone marrow histology?
Osteoporotic bone defect
Histology shows REVERSE POLARITY of basal cell nuclei, NUCLEAR HYPERCHROMATISM, NUCLEAR PALISADING, and SUBNUCLEAR VACUOLATION. What is is?
Unicystic ameloblastoma
