final on copper

Question 1

sources

Answer 1

organ meat
shellfish
nuts and seeds
legumes
whole grains

Question 2

oxidative status in the body?

Answer 2

free copper produce hydroxy radicals through fenton reaction

Question 3

enhancing factors for absorption?

Answer 3

amino acids
= histidine
= methionine
= cysteine

organic acids
= citrate
= gluconate
= lactate
= acetate
= malate

Question 4

metabolism

Answer 4

enterocytes bound to chapherone amino acids and GSH then transported to liver bounded to albumin

Question 5

when transfered to liver what happens?

Answer 5

• used for enzyme cofactor
• bind to metallothionein for storage
• transferrd to apocruloplasmin ( released in blood for tissue uptake)

Question 6

3 functions?

Answer 6

cofactor for enzymes
= ceruloplasmin
= superoxide dismutase
= cytochrome c oxidase
immune system function
never myelination

Question 7

deficiency?

Answer 7

hypochromic anemia
= copper helps iron release from the liver storage but when deficient this happens)
impaired immune function
increased demineralization of bone
cardio pulmonary dysfunction

Question 8

people at risk for deficiency?

Answer 8

consuming more than 40 mg per day of zinc
having hephrosis
GI malabsorption

Question 9

toxicity?

Answer 9

rare from food

wilsons disease

Question 10

what is wilsons disease?

Answer 10

genetic metabolic disorder

copper accumulates in liver, kidney and brain

Question 11

wilsons disease symptoms?

Answer 11

abdominal pain
nausea
liver damage
phycho neural symptoms

Question 12

what is kayser fleischer rings with wilsons disease?

Answer 12

greenish gold ring around color part of eye