Final: Lecture 31 Flashcards
0
Q
Nitrogen disposal by the urea cycle
A
- Intracellular protein turnover involves proteasomes
- Removing ammonia is key to keeping nervous tissue healthy, happens by urea cycle in the liver, the ammonia gets trapped and excreted in urine
1
Q
Protein digestion leads to absorption of amino acids and di (tri) peptides
A
- Tripsinogen hynotripsinogen, and procarboxypeptidase**
- All these get activated quickly
- Ogen = means its in its inactive state, pepsinogen
- trypsinogen –(Enterokinase)–>Trypsin
2
Q
Production of Ammonia
A
•Amino group transferred to glutamate and then released
3
Q
Trapping ammonia into urea
A
- Aminotransferase followed by dehydrogenase reaction, then urea cycle
- Transamination reaction
4
Q
Urea cycle occurs in the _____.
A
•Liver
5
Q
Be able to identify missing links, know enzyme names**
A
- Carbamoly phosphate synthetase (CPS1)–>Argininosuccinate synthase–>argininosuccinate lyase–>argininase–>ornithine transcarbamoylase
- The funneling of nitrogen occurs in the muscles, AA are then shuttled to the liver (aminotransferases help funnel)
6
Q
Oxaloacetate can go to ________ or transamination reaction to go to _______ or ________.
A
- Glucose
- Aspartate
- Glutamate
7
Q
_______ is the number 1 AA circulating in the blood, shuttles N+ to liver.
A
•Alanine
8
Q
Only two AA are stricktly ketogenis, what are they?
A
•Leucine and Lysine
9
Q
The ______ is the only thing that produces ketone bodies.
A
- Liver
* Fats will yield ketone bodies in absence of carbs