Final: Lecture 31 Flashcards

0
Q

Nitrogen disposal by the urea cycle

A
  • Intracellular protein turnover involves proteasomes
  • Removing ammonia is key to keeping nervous tissue healthy, happens by urea cycle in the liver, the ammonia gets trapped and excreted in urine
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1
Q

Protein digestion leads to absorption of amino acids and di (tri) peptides

A
  • Tripsinogen hynotripsinogen, and procarboxypeptidase**
  • All these get activated quickly
  • Ogen = means its in its inactive state, pepsinogen
  • trypsinogen –(Enterokinase)–>Trypsin
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2
Q

Production of Ammonia

A

•Amino group transferred to glutamate and then released

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3
Q

Trapping ammonia into urea

A
  • Aminotransferase followed by dehydrogenase reaction, then urea cycle
  • Transamination reaction
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4
Q

Urea cycle occurs in the _____.

A

•Liver

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5
Q

Be able to identify missing links, know enzyme names**

A
  • Carbamoly phosphate synthetase (CPS1)–>Argininosuccinate synthase–>argininosuccinate lyase–>argininase–>ornithine transcarbamoylase
  • The funneling of nitrogen occurs in the muscles, AA are then shuttled to the liver (aminotransferases help funnel)
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6
Q

Oxaloacetate can go to ________ or transamination reaction to go to _______ or ________.

A
  • Glucose
  • Aspartate
  • Glutamate
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7
Q

_______ is the number 1 AA circulating in the blood, shuttles N+ to liver.

A

•Alanine

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8
Q

Only two AA are stricktly ketogenis, what are they?

A

•Leucine and Lysine

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9
Q

The ______ is the only thing that produces ketone bodies.

A
  • Liver

* Fats will yield ketone bodies in absence of carbs

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