Final chapter questions Flashcards
In a DNA macromolecule, the sequence of _____ determines the characteristics of every living thing
Nitrogenous organic bases
How many base pairs are there in the human genome?
2.9 x 10^9
Radiation-induced chromosome damage may be evaluated during which of the following processes?
Metaphase
If exposure to ionizing radiation damages the components involved in molecular synthesis beyond repair, cells do which of the following?
Function abnormally or die
Which of the following produces antibodies?
lymphocytes
Water comprises approximately _____ of the weight of the human body
80-85%
Which of the following must the human body provide to ensure efficient cell operation?
1, 2, & 3.
1) Food as a source of raw material for the release of energy
2) Oxygen to help break down food
3) Water to transport inorganic substances into and out of the cell
Which human cell component controls cell division and multiplication as well as biochemical reactions that occur within the cell?
nucleus
What term is used to describe chemical secretions that are manufactured by various endocrine glands and carried by the bloodstream to influence the activities of other parts of the body?
hormones
somatic cells divide through the process of
Mitosis
For radiation protection, high-LET radiation is of greatest concern when internal contamination is possible, that is, when a radionuclide has been implanted, ingested, injected, or inhaled because:
Then the potential exists for irreparable damage because multiple-strand breaks in DNA are possible.
Free radicals behave as an extremely reactive single entity as a result of the presence of:
unpaired valence electrons
Which of the following are classified as high-LET radiation?
Alpha particles
Gamma rays
X-rays
Alpha particles
a biologic reaction is produced by 3 Gyt of a test radiation. it takes 12 Gyt of 250-kVp x-radiation to produce the same biologic reaction. What is the relative biologic effectiveness (RBE) of the test radiation?
4
Which action of ionizing radiation is most harmful to the human body?
indirect action
Which molecules in the human body are most commonly directly acted on by ionizing radiation to produce molecular damage through an indirect action?
water
When does ionizing radiation cause complete chromosome breakage?
When two direct hits occur in the same rung of the DNA macromolecule
When significant numbers of lymphocytes are damaged by exposure from ionizing radiation, the body:
1) loses its natural ability to combat infection
2) becomes more susceptible to bacteria
3) becomes more susceptible to viral antigens
1, 2, and 3.
1) loses its natural ability to combat infection
2) becomes more susceptible to bacteria
3) becomes more susceptible to viral antigens
With respect to the law of Bergonie and Tribondeau, which of the following would best complete this statements? “the most pronounced radiation effects occur in cells with the ______”
Greatest reproductive activity, longest mitotic phases, and least maturity and specialization or differentiation.
What do basal cells of the skin, intestinal crypt cells, and reproductive cells have in common?
All cells are radiosensitive
The total radiation dose given to a somatic or genetic cell and the period of time in which that dose was delivered determine the rate of production of
chromosome aberrations
Acute radiation syndrome presents in four major response stages. In what order do these stages occur?
prodromal, latent period, manifest illness, recovery or death
Which of the following systems is the most radiosensitive vital organ system in human beings?
hematopoietic
When cells are exposed to sublethal doses of ionizing radiation, approximately ____ of radiation-induced damage may be repaired over time and about ____ is irreparable.
90%, 10%
As radiation dose increases, the severity of early tissue reactions:
increases sharply and then gradually decreases
Prolonged exposure to x-rays in the diagnostic energy range results in high radiation dose to the skin while underlying tissues receive?
A substantially less dose
In 1898 after personally developing burns attributed to radiation exposure, this Boston dentist began investigating the hazards of radiation exposure and became the first advocate of radiation protection. Who is this person?
William Herbert Rollins
In the female, the ovarian stem cells:
Multiply to millions of cells only during fetal development, before birth, and then steadily decline in number throughout life
Which of the following types of cells develop from single precursor cell, the pluripotential stem cells?
1) lymphocytes and granulocytes
2) thrombocytes and erythrocytes
3) platelets
1,2, and 3
1) lymphocytes and granulocytes
2) thrombocytes and erythrocytes
3) platelets
With regard to radiation exposure, which part of the gastrointestinal tract is most severely affected?
small intestine
cancer and genetic defects are examples of
Stochastic effects
Some examples of measurable late biologic damage are:
1) cataracts
2) leukemia
3) nausea and vomiting
4) genetic mutations
1,2, and 4.
1) cataracts
2) leukemia
4) genetic mutations