Final broad overview

Question 1

What does Caffeine do?

Answer 1

Blocks presynaptic A-1 receptors

Increases exocytosis - excites presynaptic neuron

Question 2

What do the 5-HT agonists do?

Answer 2

Activate 5-HT2A receptors

Mimic serotonin’s effect

Question 3

What do the anti-cholinergics do?

Answer 3

Antagonize muscarinic Ach receptors

Inhibit postsynaptic neuron

Question 4

What does nicotine do?

Answer 4

Binds nicotinic Ach receptors

Agonizes Ach at postsynaptic neuron at low concentrations to excite
Antagonizes Ach at postsynaptic neuron at high concentration to inhibit

Question 5

What does THC do?

Answer 5

Partial agonist for presynaptic CB-1 receptors

Inhibits presynaptic neuron

Question 6

What do the opiate agonists do?

Answer 6

Agonize opiate receptors

Question 7

What does Cocaine do?

Answer 7

Blocks DAT, blocks Ca2+ channels

More DA in synapse after action potential

Question 8

What do the NMDA antagonists do?

Answer 8

Block NMDA receptors

Decrease LTP

Question 9

What does Amphetamine do?

Answer 9

Reverse DAT through phosphorylation
Prevent DA storage in vesicles

More base DA in synapse

Question 10

What do the opiates do?

Answer 10

Agonize opiate receptors

Inhibit postsynaptic neuron

Question 11

What does Ethanol do?

Answer 11

Agonize GABA-A
Block NMDA
Some DA increase in VTA

Inhibits postsynaptic neuron