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Pharmacology (Spring 2019) > Final - Black Boxes > Flashcards

Final - Black Boxes Flashcards

1
Q

Antituberculosis Agents

A
  1. hepatotoxicity
  2. jaundice
  3. increase LFTs
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2
Q

metronidazole

A

carcinogenic in lab animal

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3
Q

Flouroquinolones

A
  1. tendon rupture = report joint pain/weakness)

2. myasthenia gravis

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4
Q

zidovudine

A
  1. fatal lactic acidosis

2. hepatomegaly

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5
Q

aminoglycosides

A
  1. neurotoxicity (tinnitus, ototoxicity)
  2. neuromuscular blockade (resp. paralysis)
  3. nephrotoxic (check BUN/Creatinine)
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6
Q

amphotericin B

A

Don’t use nonlipid form if you don’t have to

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7
Q

Doxorubicin

A
  1. severe myselosuppression

2. cardiotoxicity = give dexrazoxane & monitor ECG changes

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8
Q

Vincristine

A
  1. myelosuppression

2. cold packs

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9
Q

Tamoxifen

A
  1. additional CA risk
  2. thromboembolic disease = blood clots
  3. endometrial cancer
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10
Q

Methotrexate

A
  1. NSAIDS
  2. myelosuppression
  3. hepatotoxic
  4. pulm. toxicity = listen to breath sounds
  5. dermatologic reactions = SJS
  6. Ulveritis stomatitis & diarrhea
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11
Q

Epoetin alfa

A
  1. cardiovascular & thrombolytic events (TIA, MI, Stroke, DVT)
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12
Q

Cyclosporine

A
  1. only admin. by PCP with experience with immunosuppressive therapy (ex. specialists only)
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13
Q

Procainamide

A
  1. lupus-like syndrome: increased ANAs

2. Blood dyscrasias - monitor CBC, discontinue at first sign

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14
Q

Amniodarone

A

causes pneumonia-like syndrome in lungs that may be fatal

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15
Q

Beta Blockers

A

Do NOT abruptly withdrawal

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16
Q

Anticoagulants

A
  • epidural or spinal hematoma
17
Q

Furosemide

A

profound diureses = water and electrolyte imbalances

18
Q

Nitroprusside Sodium

A

requires dilution prior to infusion and is not suitable for direct injection. Can cause irreversible ischemic injury and death due to significant drops in BP

19
Q

Tricyclic Antidepressants

A

Increased risk of suicide in children, teens, and young adults

20
Q

Atypical Antidepressants

A

Increased risk of suicide in children, teens, and young adults

21
Q

Lithium Carbonate

A

toxicity is closely related to serum concentrations and may occur at doses close to therapeutic levels = monitor serum levels closely and maintain within narrow range

22
Q

antipsychotic

A

not for dementia-related psychosis, increase risk of death

23
Q

Opioids

A

schedule II with high potential for physical & psychological dependence

24
Q

Benzodiazepines

A

resp. depression & arrest

Pharmacology (Spring 2019) (8 decks)

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