final Flashcards

1
Q

screening tests vs dx tests

A

screening: used to detect pathogens during sub-clinical stage

  • from exposure to clinical signs
  • early detection
  • early treatment & ↑ prognosis
  • focus: population level

dx: used to confirm or identify disease once clinical signs appear

  • guide treatment & prognosis
    focus: individual
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2
Q

measures of a test

A

validity: accuracy

reliability: repeatability

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3
Q

how do dx tests fx?

A

sense antibodies

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4
Q

false + vs false −

A

false positives can be caused by:

  • similar disease agent ➞ confusion
  • previous exposure
  • lab/test error
  • ensuring low false positives
  • important for diseases w/ $$ tx or tx that cause suffering

false negatives can occur from:

  • timing ➞ early in subclinical stage ➞ might not be long enough for immune system to begin response
  • immunocompromised indiv don’t produce antibodies so tests cannot pickup
  • ensuring low false negatives important for highly transmissible & severe diseases with extreme consequences
        - ex: PRRS
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5
Q

proportion of the population diseased and exposed

A
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6
Q

proportion of the population exposed

A
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7
Q

proportion of the population diseased

A
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8
Q

true prevalence

A

actual level of disease prevalence in the pop
* cannot know ➞ estimate using AP

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9
Q

apparent prevalence

A

what prevalence appears to be based on the test

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10
Q

sensitivity

A

proportion of D+ that T+
* how accurate the test is at identifying diseased indiv
* ↑ Sn ➞ indiv that T+ are D+

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11
Q

specificity

A

proportion of D− that T−
* how good a test is at identifying non-diseased indiv
* ↑ Sp ➞ indiv that T− are D−

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12
Q

predictive value

A

probability of disease given the test result

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13
Q

positive predictive value (PPV)

A

probability/proportion of T+ that are D+

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14
Q

negative predictive value (NPV)

A

probability/proportion of T− that are D−

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15
Q

↑ prevalence =

A

↑ PPV & ↓ NPV

more dis in pop ➞ more indiv will T+ so less indiv will T−

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16
Q

↓ prevalence

A

↓ PPV & ↑ NPV

less dis in pop ➞ less indiv will T+ so more indiv will T−

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17
Q

AP < TP

A

underestimates TP of disease ➞ more false T− so D+ are missed

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18
Q

AP > TP

A

overestimates TP of disease ➞ more false T+ so D− animals are falsely dx

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19
Q

what measures do we use to quantify disease in populations?

A
  • amount of dis
    - morbidity: # of infxt 
    - mortality: # of deaths from dis
  • temporal distribution
  • geographic/spatial distribution
  • prevalence
  • incidence
  • cumulative incidence
  • approximate incidence
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20
Q

prevalence

A

number of instances in a known pop at a specific point in time
* ** snapshot in time**
* diseases with long durations
* identifying common dis in pop
* evaluating control strategies

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21
Q

incidence

A

number of new cases in a known pop over a period of time
* preferred over prevalence
* dis w/ short durations
* understanding disease development and transmission (temporality)
* predicting risk of disease (change in health status)

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22
Q

cumulative incidence

A

proportion of non-dis animals at beginning of study that become dis during the study
* aka avg risk of developing disease during a time period
* who is getting diseased over time
* risk of disease

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23
Q

incidence rate

A

how quickly new cases develop over time
* closed pop only

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24
Q

approximate incidence rate

A

how quickly new cases develop over time for open pop

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25
closed populations
defined for entire study ➞ no additions or loses * more control * less bias * dis-free animals at start = at risk * preferred over open
26
open populations
animals enter/leave throughout duration of study * hard to keep sample size ➞ difficult to track long term * stable only if additions = withdrawals over time * not as rigorous * **cannot calculate disease risk from open pop**
27
study designs
**descriptive**: describes * summarize & describe data * no comparisons * hypothesis generating * frequency & distribution * cannot make conclusions about associations btwn E & O 1. **case report**: rare or new conditions/dis involving 1-2 animals 2. **case series**: collection of an (4+) w/ same rare condition/dis 3. **descriptive surveys**: to estimate freq & percentages of diff variables, ex morbidity, mortality, management practices **analytical**: compares * comparisons between groups * explore relationships & associations * test hypotheses 1. **experimental**: control treatments & manipulate envir 2. **observational**: natural experiments -no control over treatment or animals -no manipulation of envir -focused on exposures (E) & outcomes (O)
28
pig biology
* reach maturity at ~ 6 months of age, live up to 6-10 yrs * litters 9-13 piglets (commercial breeds) * similar biologically to humans - simple/monogastric digestive system - immune system - organs * dry skin
29
pig behavior
* intelligent – easily trained, excellent hearing and sense of smell * social animals – house in groups, have a social hierarchy * behaviors - running - scratching - swimming - mud baths - no sweat glands ➞ sensitive to heat stress - thermoregulation - parasite control
30
pork production
* pork is the most consumed meat in the world * US = 3rd largest producer/consumer of pig products, largest exporter of pig products * production – mostly indoor confinement = highly controlled, reduced disease risk, but high density (therefore disease outbreaks a concern) * US – 60,000 commercial pig farms * 115 million pigs produced each year
31
pig operations
1. **farrow-to-finish** (all in one operation) - breeding and farrowing sows - feed offspring to market weight – 280 lbs - 10-month cycle - expensive, labor intensive 2. **farrow to feeder** - gestation to nursery phase - sold for finishing - reduced operations - more economic but less profit - less need for machines ➞ less cost investment 3. **feeder to finish ** - finishing operation - reduced operations (don’t manage breeding stock) - lower labor requirements - more disease risks ➞ purchase from multiple farms, transportation, risk factors
32
coccidiosis in pigs: host
* commercial production & backyard pigs * young piglets (farrowing >10d old) * intestinal — damages G.I. tract * subclinical on most farms * sows don’t get sick ➞ sub-clinical · carriers · bring into farrowing facility * not all piglets exposed will get it * must be a stressor: smaller, poor immune function more susceptible
33
coccidiosis in pigs: agent
* protozoa, genus Eimeria (many species) * horizontal transmission: vehicle (feces) & fomites * vertical transmission: mother to offspring * pig-specific
34
coccidiosis in pigs: envir
* biosecurity: · cleaning/disinfecting areas btwn litters · quarantine * D+ piglets need warm, comfortable envir · easy access to warm milk · supportive care
35
coccidiosis in pigs: clinical signs
* diarrhea @ 10d * lethargic * weight loss or no weight gain * dehydration
36
coccidiosis in pigs: dx
* visual inspection of piglet’s clinical signs * Necropsy - Visual inspection of the intestines (dead pig) * cannot diagnostically test while alive
37
coccidiosis in pigs: tx
* anti-coccidial agents for piglets – poor efficacy, but may help if provided before GI tract damage * antibacterial agents – not practical because of meat withdrawal period of many months - production meat cannot contain antibiotics for a set # of mo * anti-coccidial disinfectants – clean between litters - most effective - easy access to milk, probiotics may help but unclear
38
streptococcus suey in pigs: host
* very common in both commercial & non - more so in commercial ➞ confined indoor housing * nursing & newly weaned * worldwide - found in all major producing facilities & countries - very prevalent in Asia - somewhat prevalent here * zoonotic: common for butchers, farmers & vets to contract * mature pigs not usually affected ➞ must have underlying stressor
39
streptococcus suey in pigs: agent
* bacterial pathogen streptococcus suey * can be clinical or sub-clinical * transmission: - direct horizontal: nose to nose contact - direct vertical transmission - indirect horizontal: ➝ vehicles — fomites ➝ mechanical — flies & rodents
40
streptococcus suey in pigs: envir
* biosecurity protocols: disinfectants kill bacteria * housing density * reducing stressors - aggression - ventilation - humidity & temp
41
streptococcus suey in pigs: clinical signs
* inappetence * weight loss or not gaining weight * fever, inflammation * lethargic * arthritis * pneumonia * shaking/convulsing ➞ it’s close to death
42
streptococcus suey in pigs: dx
* swab nasal cavities/tonsils - present without clinical infection so hard to diagnose * clinical signs and analyze farm records to assess risk factors - # impacted - age impacted - # morbidity/mortality - envir parameters: ⇾ temp ⇾ humidity ⇾ stocking density * necropsy - tissue sample, bacterial culture, and PCR testing
43
streptococcus suey in pigs: tx
* resistant to antibiotics ➞ no highly effective treatment options * prevention is key – eliminate stressors in young pigs, biosecurity, control of other diseases * developing vaccine: - give to mother ➞ vertical transmission through antibodies in colostrum until 4w - bacterial gene sequencing
44
porcine reproductive & respiratory syndrome (PRRS) suey in pigs: agent
* PRRS Virus (genus Arterivirus) - PRRSV-1 (European origin) - PRRSV-2 (N. American origin) * clinical presentations: - breeding animals ➞ reproductive impairment - all pigs/ages ➞ resp disease * very infectious * vertical transmission * horizontal transmission: - vehicles ➞ fomites, semen, food, water
45
porcine reproductive & respiratory syndrome (PRRS) suey in pigs: host
* commercial production * all ages * worldwide * sow can contract during breeding & artificial inseminations * most infected pigs become immune
46
porcine reproductive & respiratory syndrome (PRRS) suey in pigs: envir
* biosecurity btwn age groups * quarantine/test new animals * vx ➞ not very effective * early weaning & isolation of new liters * no mixing ages
47
porcine reproductive & respiratory syndrome (PRRS) suey in pigs: clinical signs
* fever * lethargy * poor growth * dyspnea, sneezing * vomiting (older animals) * reproductive problems ➞ unique so key clinical sign for identification - premature - stillborn - mummified fetus - weak piglets * 2° infx ➞ infected with other pathogens (virus, bacteria) - ex: influenza, porcine respiratory coronavirus, Mycoplasma hyopneumoniae
48
porcine reproductive & respiratory syndrome (PRRS) suey in pigs: dx testing
* blood sample ➞ PCR or ELISA test · ELISA test: antibody test · PCR: detects genetic material * necropsy – tissue sample (lung preferred), PCR or ELISA
49
porcine reproductive & respiratory syndrome (PRRS) suey in pigs: tx
* no effective treatment * exists on most farms * reduce severity - improve comfort - easy access to food/water - ↓ stress * reduce number of infections - ↓ stocking density - improve biosecurity measures * establish a control program & monitor disease
50
feline biology
* spay/neuter after 4 months of age (sexual maturity) * excellent vision in day & night - blue & green - far sighted - can track fast-moving objects very well but not slow-moving objects * excellent hearing – large range of sounds * high and low frequencies * high ➞ mice & rats * olfactory communication * vomeronasal organ detects/processes odors (flehmen response) * sebaceous scent glands ➞ pheromones
51
feline behaviors
* solitary predatory hunters ➞ carnivores * eat alone * territorial ➞ need own space & access to resources * live in groups * form strong social attachments with familiar people & conspecifics (usually close kin) * scratching ➞ scent distribution & claw maintenance * stretching * perching ➞ visualize envir & feel safe/secure * climbing * hiding * hunting * playing
52
feline diseases
1. Feline idiopathic cystitis 2. Feline panleukopenia 3. obesity
53
Feline idiopathic cystitis
feline lower urinary tract infx * Who: adult & senior cats * Major Risk Factor: Stress plays an important role * Prevention/management: * Encouraging increased water intake ➞ frequent urination = urine is more dilute ➞ less irritating bladder cells * urinary diet * maintain consistent home environment and try to reduce stressors/changes
54
Feline idiopathic cystitis clinical signs
* straining to urinate * bloody or discolored urine * frequent urination * accidents * inability to urinate
55
Feline panleukopenia
feline parvo * **Who**: Kittens & unvaccinated adult cats * Mostly animal shelters, boarding facilities, & unvaccinated community cat colonies * **Agent**: Feline parvovirus. (Gastro-intestinal disease) * **Major risk factors** * Keeping unvaccinated/unknown vaccination status cats/kittens together * Letting unvaccinated cats/kittens outside (exposed to infected cats/kittens). * **Prevention/management**: * Vaccines * Health management plan in shelters/kennels
56
Feline panleukopenia clinical signs
* depression * loss of appetite * high fever * lethargy * vomiting * severe diarrhea * nasal discharge * dehydration * sit for long periods of time in front of their water bowls but not drink much water
57
feline obesity
* **Who**: mostly adult &senior cats * **Agent**: no pathogen * **Major risk factors**: * free-feeding * lack of exercise/low activity levels * boredom/little mental stimulation * indoor-only cats * **Prevention/management**: * weight-reduction program (weight control food) ➞ want slow weight loss though controlled feeding multiple times a day * Ensure good activity levels - play time, cardio, leash walks, etc * Food puzzles ➞ work for their food!
58
feline obesity clinical signs
* Difficulty jumping or climbing stairs * Sitting or lying down more and showing an unwillingness to get up and move around * Loss of a visible waistline * Inability for pet parent to feel rib bones or hip bones
59
canine biology
* spay/neuter 6 - 9 months of age (sexual maturity; depends on the breed) * good vision * see in blues & yellows * low-light * red = gray * excellent hearing * good range of sounds ➞ high frequencies * can hear up to 80ft away * olfactory communication * paired vomeronasal organ detects/processes odors (flehmen response) ⇾ teeth chattering to smell / detect / investigate * sebaceous scent glands ➞ pheromones
60
canine behavior
* highly social * live in groups * form strong social attachments with familiar people, and conspecifics * carnivores * territorial * play and exercise * social environment * cognitive stimulation
61
caninee diseases
1. canine parvovirus 2. hypothyroidism 3. osteoarthritis
62
canine parvovirus
* **Who**: unvaccinated dogs and puppies, but can infect all dogs * **Agent**: Highly contagious gastro-intestinal virus: Canine parvovirus 2 * **Major risk factors**: * unvaccinated dogs/puppies kept together * use caution when bringing pets to places where young puppies congregate (e.g. pet shops, parks, puppy classes, obedience classes, doggy daycare, kennels, and grooming establishments) * letting your puppy or adult dog to come into contact with the fecal waste of other dogs while walking or playing outdoors * **Prevention/management**: Vaccination and good hygiene are critical components of prevention * Puppies should receive canine parvovirus vaccine
63
canine parvovirus clinical signs
* lethargy * loss of appetite * abdominal pain and bloating * fever or low body temperature (hypothermia) * vomiting * severe bloody diarrhea
64
canine hypothyroidism
hormone imbalance of thyroid gland * **Who**: adult dogs 4–10 years old * Usually affects mid to large breeds & rare in toy/miniature breeds * Some breeds carry higher risks such as golden retrievers * **Agent**: No agent * Hypothyroidism develops from an underactive thyroid condition * relatively common endocrine disorder in dogs * **Major risk factors**: Certain breeds & M:I dogs have higher risk * **Prevention/management**: no prevention, but routine veterinary visits can catch it early * Medication can manage the disease effectively as long as the owner can give the medication to the pet
65
canine hypothyroidism clinical signs
* weight gain without an increase in appetit * lethargy and lack of desire to exercise * cold intolerance * dry, dull hair with excessive shedding. * very thin to nearly bald hair coat. * increased dark pigmentation in the skin
66
canine osteoarthritis
* **Who**: mature and senior dogs, & larger breeds more at risk * **Agent**: None, reduces mobility and causes pain * **Major risk factors**: * obesity * lack of exercise * can be related to genetics and aging * **Prevention/management**: * Diet and weight control * reduce high impact activities * encourage low- impact activities to help improve/maintain joint mobility * Rehabilitation such as therapeutic exercises (i.e., swimming, underwater treadmill), can help improve join mobility * Pain control important * Joint supplements may help
67
canine osteoarthritis clinical signs
* Pain * stillness and lameness * Swollen joints * Refusal to jump, use stairs or run * Reluctance to stand up
68
aquaculture includes
* all fish/seafood * farmed fish * sustainable fish * conservation * recreation ➞ coy ponds * scientific ➞ biomedical research * regenerative purposes ➞ kelp
69
types of systems
1. Recirculating Aquaculture Systems (RAS) ➞ fish culture tank ➞ mechanical filter ➞ biological filter ➞ oxygenation ➞ water inputs ➞ fish culture tank 2. Pond systems ➞ squares in fields (catfish, bass, sturgeon) 3. Flow-through/raceway ➞ good for high O2 demand & river nearby 4. Aquaponics ➞ for limited H2O supply ➞ effluent from tank waters plants (N2) 5. Open water (fish) ➞ giant circular nets in ocean (not common in US) 6. Open water (shellfish/seaweed) ➞ drag along nets 7. Integrated Multi-Trophic Aquaculture (IMTA) ➞ net of fish producing waste & position shellfish/kelp around to take up nutrients in waste ➞ makes more eco-friendly
70
Major challenges in aquaculture
* Intensive, semi intensive, extensive production systems * Disease outbreaks - Sources of disease (ambient/environmental pathogens, contamination) - Factors influencing disease outbreaks ⇾ Aquatic environment-–transmission is easier relative to terrestrial pathogens ⇾ Stress from crowding, handling, diet, weather, etc * Emergent pathogens * Resistant diseases, limited treatment solutions
71
sea lice
* Parasitic crustacean * Naturally present in marine environments * * **host**: * Atlantic Salmon * All life stages * Adaptive/innate immunity * Standardized diet * **agent**: * known lifecycle * locally transmitted * **envir**: * semi-intensive * high stocking-density
72
Lactococcus garvieae
* Pathogenic strain of bacteria * Highly infectious and deadly * Unknown source but likely came from birds * **host**: * raibow trout * all life stages * adaptive/innate immunity * standardized diet * **agent**: * bacteria * resistant to abx * locally transmitted * **envir**: * intensive systems * warm temp * high stocking-density
73
aquaculture dis tx
* Environment manipulation * Temperature, salinity * Biological control, i.e., cleaner fish for parasite control * Antimicrobial products * Broad spectrum – disinfection, sterilizing, external parasites * Therapeutic – bacterial infections * Culling infected individuals
74
AMR in aquaculture
* around world: Chile, China, India – AMR detectable in environment near aquaculture * US: Strict regulations ➞ AMR present in emerging pathogens * Policies and actions to slow development of AMR * Required Rx for antibiotics * Environmental/system monitoring * Alternative strategies for disease treatment
75
3 levels of aquaculture dis prevention
1. comprehensive protocols - Biosecurity: standardized cleaning and contamination protection - Disease response: Quick and appropriate response to signs of disease 2. good husbandry strategies - stress management - proper diet + sustainable ingredients - optimal envir 3. effective antimicrobial products - biocides - antimicrobials ➞ FDA approved for use as dis tx - abx ➞ Classified as MIADs, FDA approved for use only as disease treatment and only under veterinarian guidance * not used for growth promotion
76
alternative methods
* stock selection * vaccines * novel antimicrobials * dietary supplements
77
signs of a healthy horse
1. Normal Behavior/Demeanor * Normal Vital Signs * Eating * Not standing alone * Normal Body posture 2. Good Body Condition * Scored from 1 to 9 * 5 (moderate) or 6 (moderate to fleshy) * Very thin (1) or obese (9) = unhealthy 3. Hair Coat * Shinny, glossy hair= 1 of the best indicators * Often relates to nutrition & deworming program 4. Hoof Growth * Healthy hoof wall tissue * 1⁄4 to 1⁄2 inch/month (6-8 w clipping) * Smooth and uncracked 5. Eyes * Bright eyes * fully open, clear no discharge, not glazed over or dull 6. Manure/Urination * Firm manure (not loose or watery) * Wheat straw (not cloudy or dark red) * Indicator or hydration/illness
78
signs of pain in horses
1. Restlessness, Agitation, Anxiety 2. Rigid stance, reluctance to move 3. Lowered head carriage 4. Fixed stare, dilated nostrils, clenched jaw 5. Aggression towards own foal or people
79
how to manage horse health & prevent disease
1. Proper Nutrition: feed according to: · Exercise Level · Reproduction Status · Age · Growth Rate · Mature Body Weight · Temperature (extreme cold) 2. Prevention and control of Parasites 3. antibodies/vx
80
how to control external and internal parasites in horses
* sanitation & good management * chemical applications * feed products * fly apparel
81
core vs risk-based vx for horses
core: * Eastern/Western Equine Encephalomyelitis * Rabies * Tetanus * West Nile Virus risk-based * Anthrax * Botulism * Equine Herpesvirus (Rhinopneumonitis) * Equine Influenza
82
equine colic
* digestive disease * Abdominal pain or discomfort * Symptoms: * Increase in TPR * sweating * panting * rolling * Can lead to surgery or death * Prevention: - Regular parasite program - Maintaining a regular feeding program - Avoiding sudden dietary changes - Providing water at all times
83
equine colic clinical signs
* Increase in TPR * sweating * panting * rolling
84
Laminitis
inflammation of the laminae * Founder displacement of the coffin bone in the hoof * Clinical signs: Inflammation of the lamina * lameness * NWB * shifting weight * increased TPR * Causes: * dietary changes * decreased glucose to the lamina * constricted blood flow * dystocia or retained placenta * stress * infection * high temperature
85
Laminitis clinical signs
* lameness * NWB * shifting weight * increased TPR
86
abnormal repetitive behaviors (ARBs)
captive specific behaviors that indicate a physiological problem or envir stressor or deficiency 1. sham-chewing: chewing air ➞ produces foam * mechanism: food-related frustration ➞ not enough food compared to what they normally eat * pigs 2. back-flipping * mechanism: cognitive impairment ➞ developmental * basal ganglia: region of the brain responsible for behavioral inhibition or control ➞ regulation * damage increases locomotive behaviors 3. self-mutilation: behaviors results in direct increase in serotonin or lower corisol (measure of stress) * feather-plucking * skin-picking
87
dairy cattle ABRs
1. tongue rolling ➞ mimicking eating grass 2. non-nutritive oral manipulation (NNOM) * weaning associated * resemble nat behaviors like drinking milk or foraging * limited understanding of development
88
similarities & diff btwn dairy & beef cattle
**beef**: * primary product is beef * calves born on pasture * raised by mom for 6-8m (nearly 1/2 of life) * moved into feedlot around 12m * fed concentrate diet ➞ high-calorie corn-based * slaughtered by 14-16m * mostly outdoor housing * little to no human interaction * left out on own in pasture **dairy**: * primary product is milk * calves born and removed from mom immediately (w/in 24h) * farmers main argument: avoid dis (not well supported) * most evidence supports counterargument * housed individually until weaning (6-8wk) then grouped * bred by 14-16 mo, calve 22-24m * feed-restricted * kept on farm on avg. for 3 lactation cycles ➞ then slaughtered * mostly housed indoors/under cover * lots of human interaction
89
scours in cattle
* leads to dehydration * leading cause of death in calves <1m **clinical signs**: * very watery diarrhea that runs through bedding ➞ hard to identify b/c runs through hay * signs of dehydration * signs of weakness: * lethargy * droopy ears * laying more frequently ➞ tricky to identify b/c calves lay down a lot * not eating **causes**: 1. Infectious: cause inflammation of intestines affecting nutrient absorption * bacteria (e.g. E coli) * Viruses (e.g. Rotavirus) * Parasite (Cryptosporidium) 2. non-infectous: poor nutrition or milk quality ➞ watery & doesn’t have nutrients & consistency that it should
90
scours in cattle: clinical signs
* very watery diarrhea that runs through bedding ➞ hard to identify b/c runs through hay * signs of dehydration * signs of weakness: * lethargy * droopy ears * laying more frequently ➞ tricky to identify b/c calves lay down a lot * not eating
91
scours - one health
**human**: zoonosis & costly **animal**: welfare ➞ suffering, death, dehydration, pain, severe weight loss **envir**: dirty pens/envir ➞ leads to reinfection
92
Bovine Respiratory Disease (BRD)
leading cause of morbidity in in heifers (dairy cattle) & feedlot beef cattle **clinical signs**: * nasal and eye discharge ➞ 1st sign of infx * shallow or fast breathing & coughing * fever or low appetite ➞ hard to identify in large heard * sunken eyes * low head * droopy eyes * emaciated **causes**: 1. Infectious: often virus 1st then 2° bacterial infx due to weakened immune sys 2. non-infectous: envir factors * Cleanliness * ventilation * overcrowding * transport
93
Bovine Respiratory Disease (BRD) clinical signs
* nasal and eye discharge ➞ 1st sign of infx * shallow or fast breathing & coughing * fever or low appetite ➞ hard to identify in large heard * sunken eyes * low head * droopy eyes * emaciated
94
Bovine Respiratory Disease (BRD) & one health
**human**: * $$$ tx * AMR * perception of abx ➞ consumers don’t want milk tx abx **animal**: death, welfare, suffering **envir**: * poor ventilation * overcrowding * methane ➞ GG * AMR
95
Mastitis
inflammation of the mammary gland ➞ leads to low milk production (main concern for farmers) **sub-clinical mastitis**: * asymptomatic * can be detected by testing milk for somatic cell counts (SCC) **clinical mastitis**: * visibly abnormal milk * udder changes **clinical signs**: * milk is thicker & more yellow (normally liquid & clear/white) * Udder is red and swollen * usually only present in 1 quarter of udder **causes**: 1. Infectious: bacteria in the teat canal (often streptococci or gram-negative rods 2. non-infectous: envir factors → damage or injury to the teat often caused by machinery or trauma
96
Mastitis clinical signs
* milk is thicker & more yellow (normally liquid & clear/white) * Udder is red and swollen * usually only present in 1 quarter of udder
97
Mastitis & one health
**human**: * AMR * perception of abx use * $$ concern ➞ no mastitis milk going into tank ➞ loss of $$ * unclean milk **animal**: pain & chronic culling **envir**: * dirty envir, cleaning equipment * AMR
98
3 models of animal welfare
1. 5 freedoms 2. 3 circles ➞ physical & natural lead to mental (US) 3. 5 domains ➞ most comprehensive (AUS)
99
dimensional view of affective states
**arousal**: physiological functioning * cannot distinguish +/− w/ arousal state ➞ terrified & excited both elicit same arousal **valence**: +/−
100
to assess population-level animal welfare:
* morbidity & mortality * incidence & prevalence