FHx and Breast Cancer Flashcards
1
Q
What % breast and ovarian cancer is hereditary
A
5-10%
2
Q
Breast CA risk factors
A
Early menses first birth > 30 Nulliparity menopause > 55 alcohol radiation previous Fhx of breast cancer
3
Q
Ovarian CA risk factors
A
Nulliparity
FHX of ovarian cancer
4
Q
Are BRCA mutations recessive or autosomal dominant
A
autosomal dominant
5
Q
What is Li Fraumeni syndrome
A
TP53 gene
linked to breast ca around 33 yrs
6
Q
What is Peutz-Jegher’s syndrome
A
STK11 gene
increase risk breast cancer by 32% by 60
7
Q
What is Cowden syndrome
A
PTEN gene
25-50% breast cancer risk
8
Q
What is Ataxia Telangiectasia syndrome
A
ATM gene
increase breast cancer risk
9
Q
What is key to genetic counseling
A
Family History
10
Q
What are suspicious for hereditary cancer symptoms
A
Cancer > 2 close relatives
Early age diagnosis
Multiple primary tumors
Bilateral or multiple rare cancers
11
Q
What are red flags for hereditary breast and ovarian cancers
A
breast
