Conditions/Diseases Flashcards
Turner Syndrome Summary
Def: genetic abnormality in women
Cause: 45, XO chromosomes
Eval:
SS: amenorrhea delayed puberty webbed neck small stature poor breast development coarctation of aorta
Txt:
growth hormone
estrogen - during puberty
progestins - later to prevent endometrial hyperplasia
Excess Androgens Summary
Def: overproduction at adrenal glands, ovaries, extraglandular
Cause: Polycystic Ovary Syndrome Hormone secreting tumors Adrenal disorders - congenital adrenal hyperplasia - cushing syndrome Idiopathic Hirsutism
SS: Hirsutism Virilization structural - imperforate hymen - transverse vaginal - bicornate uterus - mullerian agenesis
Follicular phase summary
Def: onset of menses to LH surge/ovulation
Duration: variable, 14 days
Activity:
FSH increase
- follicular growth of oocytes
- emerge dominant follicle (23 chromosomes)
Menstuation
- first 3 - 7 days
- blood/desquamated superficial endometrial tissue
- prostaglandins cause cramping
Estradiol
- maintain endometrium
- start low and then increase to cause LH burst
Ovulation summary
Def: release of oocyte
Activity:
LH surge cause ovulation
oocyte released from ovary
follicle becomes corpus luteum (release progesterone)
Luteal phase summary
Activity:
Progesterone secreted by corpus luteum
- suppress FSH and LH
Fertilization:
- implanted zygote release human chorionic gonadotropin
- sustains corpus luteum until placenta take over (9 - 10 weeks)
No Fertilization:
corpus luteum involutes 9 - 10 days
- cause increase FSH
Oogenesis summary
Cause: FSH stimulation
Activity:
several primary oocytes grow
- 1 or 2 resume meiosis I
* cause secondary oocyte
primary follicle develop granolas cells around secondary oocyte
- releases 2nd oocyte and become corpus luteum
corpus luteum secrete progesterone and estrogen to support 2nd oocyte if fertilized
Amenorrhea summary
def: absence of menstruation
primary - none by 13 yrs or 15yrs with 2nd sexual development
secondary
- no menstruation 3-6 months
cause: preg hypothalamic ovarian genital outflow obstruction
Anovulation summary
def: failure to ovulate
cause:
HPO
systemic disease
medications
SS:
constant estrogen levels
irregular, unpredictable bleed
Ovulatory bleeding summary
Metorrhagia - bleed between cycles Menorrhagia - excessive bleed regular intervals Menometrorrhagia - frequent/excessive bleed Polymenorrhea - frequent bleed
Cause: Obstetric GU tract abnormal HPO axis anovulatory bleeding meds dysfunctional uterine bleeding
Fibroadenoma
Most common solid mass found in women of reproductive years (15-50)
Symptoms: firm, round, well circumscribed, mobile mass
Dgx: classic US appearance and/or needle bx
Tx: does not require excision, although most women prefer it
Mastitis/Abscess
Causes: pregnancy/lactation, injury, nipple piercing
Symptoms: pain, swollen, erythematous breast
Tx: Abx
Mammogram or US to r/o abscess
Lobular carcinoma in situ
*Misnomer-NOT a cancer, but is a risk factor for developing invasive cancer
Risk may be increased as much as 20-30%
Tx: close observation, bilateral prophylactic mastectomy. tamoxifen
ductal carcinoma in situ
Abnormal appearing microcalcifications
Proliferation of malignant cells within ducts
Stage 0
Tx: lumpectomy/Radiation therapy, mastectomy, no lymph node dissection, no chemo, possibly tamoxifen
invasive ductal/lobular carcinoma
invades beyond the normal duct/lobule into surrounding tissue
lobular carcinoma can be more diffuse and difficult to detect by mammography because it grows linearly
most common sites of metastasis: Lung, Liver, Bone, Brain
Tx: all patients need axillary lymph node bx for staging; lumpectomy/chemotherapy, mastectomy, chemotherapy/hormone therapy
Inflammatory Breast Cancer
stage 3b, poor prognosis
Signs: swollen, usually nontender breast, erythema, peau d’orange, may not have dominant mass
Tx: preoperative chemotherapy first, mastectomy and axillary lymph node dissection, radiation, hormone therapy
Paget’s disease
signs: eczematous changes of the nipple
associated with underlying invasive cancer
dgx: with nipple bx
Tx: usually tx with mastectomy, if underlying cancer identified can do central lumpectomydysuria
Lichen sclerosus summary
Def: inflammatory condition of the valva
Cause: autoimmune
SS: vulvar pruitis vulvar pain dysuria dyspareunia white, wrinkled skin on labia
Eval:
punch biopsy
Txt: Topical steroids (2-3 mths and then weekly)
Lichen simplex chronicus summary
Def: lichenified skin reaction to chronic scratching
Cause: atopic dermatitis, cadidia, tinea
SS:
progressive pruritis
progressive burning
red papules form scaly plaques
Eval:
clinical
Txt:
underlying cause
antipruritis meds
topical steroids
Lichen planus summary
Def: inflammatory condition
Cause: autoimmune in older women
SS: chronic pruritis dyspareunia post-coital bleeding red/white, patchy, ulcerative lesions
Eval:
Clinical
Biopsy
Txt:
topical steroids
oral prednisones
Psoriasis summary
Def: genital involvement during menarche, pregnancy, menopause
Cause: autosomal dominant
SS:
pruritic
scaly, silvery patch on erythematous base
Eval:
Biopsy
Txt:
Topical steroids
Dermatitis Summary
Def: dry skin
Cause: eczema and seborrheic dermatitis
Eval:
Clinical
Txt:
offending agent
topical steroids
Vestibulitis summary
Def: localized vulvar pain without dermatitis
Cause: unknown
SS: severe pain on touch vulva
dyspareunia
small, reddened patchy areas
Eval:
light touch over vestibule recreate pain
Txt: Topical lidocaine notripyline gabapentin abstinence
Bartholin gland cyst summary
Def: obstruction of bartholin glands
Cause: bacterial cause
SS:
asymptomatic
pain and tenderness
firm swelling of posterior vaginal introitus
Eval: clinical
Txt:
word catheter
Vulvar neoplasia summary
Def: cancer of vulva
Most common vaginal intraepithelial neoplasia (from another site)
SS:
irritation
pruritus
raised lesions
Eval:
Biopsy
Txt:
Excision
Vaginal Cancer summary
Def: squamous cell, adenocarcinoma, melanoma
Not common
Cause:
HPV
Vaginal Intraepithelial Neoplasia
Cervical cancer
SS:
asymptomatic
vaginal bleed
Eval:
pap
biopsy
Txt:
radiation
hysterectomy
upper vaginectomy
Benign Cervical Tumors summary
Nabothian cysts - squamous over columnar cells in cervix
Polyps - polypectomy if symptomatic
Cervical Cancer summary
Cause: HPV but if have won’t mean get cancer
SS: precursor lesions by 10 yrs asymptomatic watery vaginal discharge spotting
Eval:
Pap test
colposcopy
conization
Txt: conization of cervix hysterectomy lymph node dissection radiation therapy
Uterine Leiomyoma Summary
Def: localized proliferation of smooth muscle cells
Cause:
Estrogen
SS:
masses in uterus
abnormal bleeding
Menorrhagia (anemia from it)
Eval:
clinical
US
Txt:
myomectomy
hysterectomy
Adenomyosis summary
Def: benign endometrial glands and stroma in uterine musculature
SS:
menorrhagia
dysmenorrhea
enlarged uterus
Eval:
MRI
histology
Txt:
hysterectomy
Endometrial polyps summary
Def: benign focal processes in perimenopausal women
SS:
abnormal bleeding
pelvic pain
Eval:
US
Txt:
polypectomy