Fetal Infections ABC

Question 1

Listeriosis in pregnancy

Answer 1

granulomatosis infantiseptica. Infants with this disorder have disseminated abscesses and/or granulomas in multiple internal organs

Most neonates with granulomatosis infantiseptica are stillborn or die soon after birth

Neonates probably acquire infection during or after birth. Infection in the first week of life is usually manifested by sepsis, while disease manifestations after the first week are more variable and often include meningitis.

ampicillin (2 g IV every four hours)
7-day course of antibiotic therapy with oral amoxicillin (500 mg 3 times daily or 875 mg 2 times daily)

Question 2

CMV vertical transmission

per trimester

Answer 2

Increased risk for vertical infections from 35-65% with primary

later trimesters- less symptomatic

Question 3

Congential syphilis

Answer 3

hepatomeagly
placentomegly
anemia
polyhydramnios
hydrops
-1/3 of affected fetuses are stillborn 
- most likely if delivery occurs within 30 days of delivery 

• invasive testing not recommended

Question 4

toxo transmission rates per trimester

Answer 4

similar to CMV increases with gestation
- u/s also similar to CMV

palo alto labs for serology!!!

Question 5

congenital toxo

Answer 5

40% severely affected

• CP microcephaly blindness hydrocephalus epilepsy death

Question 6

treatment for CAP

Answer 6

amoxicillin or amoxicillin/clavulanate plus azithromycin