Female Reproduction Flashcards
Oogenesis, reproductive cycle
Follicle Stimulating Hormone (FSH)
Gonadotropin Stimulates follicular growth
Receptor on granulosa cells
Synthesized & released by anterior pituitary
Stimulated by GnRH Inhibited by inhibin, estrogen
Continuation of Oogenesis
Oocyte remains quiescent in prophase I until LH surge (puberty)
Uterine Contractility (for sperm transport)
Oxytocin → Ferguson’s reflex
PGF2alpha (from seminal plasma)
Estrogen (from seminal plasma)
Polytocous
litter-boring animals (multiple offspring)
Primordial Germ Cells (PGCs)
Stem cell of oogenesis
Migrate from yolk sac to genital ridge
Tertiary/Antral Follicle
Fluid-filled cavities form between granulosa cells (form antrum)
Theca differentiation (theca interna & externa)
Luteolysis
Regression of CL (if female fails to become pregnant)
Dec. P4
PGF2alpha released from endometrium (uterus must be present in animal)
Meiosis
Diploid cell (2n) -> haploid cell (n) # of xsomes reduced so resulting cells only have one copy of each homolog
Progesterone (P4)
Produced by CL (& placenta in horse, sheep, cow)
Maintains pregnancy
Inhibits estrous behavior, GnRH & LH secretion, synthesis of oxytocin receptors
Supersedes effects of estrogen
Simplex Uterus
No uterine horns
Ex. Primates
Anestrus
Time when female is not cycling
Ex. seasonal, pregnancy, lactation, stress (low BCS), pathology
Utero-tubal Junction (UTJ)
Sperm barrier
Selectively allows transport of morphologically normal spermatozoa
Theca Interna
Layer of tertiary follicle
LH responsive
Steroidogenic (androgen)
Telophase I
Two unequal daughter cells formed (secondary body & polar body), each with 1 copy of homologous xsome pair
Hypothalamic-Pituitary-Gonadal (Ovarian) Axis
Hypothalamus (GnRH) → Anterior Pituitary (LH & FSH) → Ovary (inhibin, estrogen, progesterone)
Mitosis
Diploid cell (2n) -> diploid cell (2n)
Two identical daughter cells
Oogonia
PGCs that have reached genital ridge, lose motility Multiply by mitosis Interconnected by cytoplasmic bridges
Metestrus
Formation of CL Dec. estrogen
Incr. P4
Female no longer receptive
Oogenesis
Formation of female gamete
Starts from undifferentiated stem cell (2n) of early embryo and is completed after fertilization
Estrus
Behavioral receptivity & mating occur
High estrogen
Low P4
Ovulation (most spp.)
Partial Uterectomy (Ipsilateral to CL)
CL lifespan longer than normal (35d - sheep)
Polyestrous
Repeated estrous cycles uniformly distributed throughout year
Ex. cattle, swine, rodents
2nd Meiotic Division
Second meiotic arrest at metaphase II
Remains quiescent until fertilization