Female Physiology Flashcards
androgens stimulate what cells
granulosa cells
estrogen inhibits what
GnRH
LH
FSH
Granulosa cells inbits
FSH secretion
What regulates thecal cells
LH
What regulates granulosa cells
LH and FSH
E2
estradiol
E1
estrone
E3
estriol
what hormone is predominant during pregancy
estriol (E3)
what hormone is predominant during menopause
estrone (E1)
what hormone is predominant during reproductive year
estradiol (E2)
how carbons does all estrogens have
18
Functions of Estrogen
- maturation and 2nd sex characteristics
- increase CNS excitablity
- Stimulate endomerial prolif. and uterine growth
- maintenanceof blood vessels and skin
- increase plasma serum hormone bind globulin
- reduce rate of bone re-adsorption
- alter plasma lipds (increase HDL and tri., lower LDL)
- enhanced blood coagulabilty
what point of the cycle is estrogen at its low point
menses
what stimulates hte growth of several preovulatory ovarian follicles
FSH and LH
LH act predominantly on
theca cells
FSH act predominantly on
granulosa cells
what inhibits FSH and LH
increase E2
where does FSH and LH accumulate during prolong levels of E2
anterior pituitary
What causes LH to surge
Temporary flip feed back from neg to pos. stims hypothalamusro release moreGnRH
what does the LH surge cause
ovulation
how long does the luteal phase last
begins at ovulation and last 14 days
What inhibts the pituitary from releasing LH and FSH
elevated progesterone (and estrogen) in the blood
What phase does the uterus change its lining
secretory phase
What causes the changes in the lining of the uterus
progesterone
after ovulation, what does the granulosa cell start to produce in the corpus luteum
progesterone
Where are prgestin synthesized
overary testes and adrenal cortex from cholesterol
carbon back bone of progestins
21
Physiological effects of progesterone
- prepares uterus for implant
- devel. of secretory mech of breast
- increase fat deposition
- Decrease CNS excitabilty
- increase insulin
- increase aldoserone
- increase body temp
- decrease pC02
what hormone is invouled with body weight and puberity
leption
what could be cause of menopause
loss ininhibins (loss of inhibition for FSH
what hormone at menopause is elevated
FSH
upon implantation, trophoblast start secreting what
hCG, LH like
what dies hCG prompts
the corpus luteum to continue expressing estrogens and progesterone
what prevents menstruation
hCG