Female Genital Tract - Amy Flashcards
Endocervix has what epithelium?
Single layer of columnar
What is and what causes squamous cell hyperplasia?
Histology?
Premalignant?
Small flat papule, due to chronic rubbing or scratching to relieve itching
Hyperkeratosis w/thickened epidermis w/some lymphocytes
NO
What causes a condylomata Acuminatum?
Viral change called what?
HPV 6 and 11
Koilocytic atypia
What may develop in older women due to long standing lichen sclerosis or squamous cell hyperplasia?
Keratinizing SCC
What is composed of loose fibromyxomatous stroma covered by mucus-secreting endocervical glands often accompanied by inflammation?
Causes what?
Endocervical polyps
Irregular vaginal spotting
What is in Gardasil?
Vaccine for HPV 6, 11, 16, 18
Small-cell neuroendocrine tumors of the cervix have what prognosis?
VERY poor
Basaloid and warty carcinomas caused by what?
HPV 16
What is the next step when a PAP smear is abnormal?
Colposcopic exam of cervix and vagina
Then biopsy if needed
DES is associated with what rare cancer?
Clear Cell adenocarcinoma
Blockage of mucosal glands in cervical area causes what?
Nabothian cyst
Neuroendocrine cervical carcinoma has an appearance similar to what?
What is different?
Small cell carcinoma of the lung
(+) for high risk HPV
HPV + what co-carcinogens cause cancer of the cervix?
Cigarettes
Microbial infections
Hormone changes
Diet deficiency
What epithelium is the vagina?
SSNK
Cervical Moderate Dysplasia is what CIN?
Severe?
CIN II
CIN III
What benign entity produces pain and discomfort, and results from obstruction of a duct in females?
Bartholin Cyst
Cervical carcinoma avg age?
What types?
45
SCC (80%)
Adenocarcinoma (15%)
Mixed/neuroendocrine (5%) –> worst prognosis
Koilocytic atypia is from what?
HPV
Cambium layer?
Sarcoma botyroides
5yr survival for microinvasive cervical carcinoma?
100%
Cervical Mild dysplasia is what CIN?
What squamous intraepithelial lesion classification?
CIN I
LSIL
Lichen Sclerosis occurs in whom?
Described as what?
Increased risk of what?
Postmenopausal women
Leukoplakia that is paper thin w/T cell infiltrate
SCC
What is upregulated and useful in diagnosing SIL in HPV (+) cases?
Ki-67
P16
Ectocervix has what epithelium?
SSNK
What has the same histology as intraductal papilloma of the breast and is a sharply-circumscribed nodule found on the labia majora which can ulcerate?
Papillary Hidradenoma
What is is an intraepithelial proliferation of malignant cells w/pale cytoplasm w/MPS staining PAS (+)?
Extramammary Paget
What occurs in infants and children < 5 y/o and can cause death by penetration into the peritoneal cavity or by obstructing the urinary tract?
Embryonal Rhabdomyosarcoma
Tumors affecting the upper vagina spread to what LNs?
Lower 2/3rds?
Regional iliac
Inguinal
What presents as a pruritic, red, crusted, maplike area usually on the labia majora?
Means what?
Extramammary Paget Disease
NOT necessarily cancer
What may cause septation (double vagina) or vaginal adenosis?
DES
What is common along the lateral wall derived from the Wolffian (mesonephric) duct in the proximal vagina?
Gartner duct cyst
What is cytokeratin 7 (+)?
Extramammary Paget’s
Which vulvar intraepithelial neoplasia is a pre-malignant lesion?
Has what morphology?
Differentiated
Central keratin pearls
