Female Genital Tract - Amy

Question 1

Endocervix has what epithelium?

Answer 1

Single layer of columnar

Question 3

What is and what causes squamous cell hyperplasia?

Histology?

Premalignant?

Answer 3

Small flat papule, due to chronic rubbing or scratching to relieve itching

Hyperkeratosis w/thickened epidermis w/some lymphocytes

NO

Question 4

What causes a condylomata Acuminatum?

Viral change called what?

Answer 4

HPV 6 and 11

Koilocytic atypia

Question 5

What may develop in older women due to long standing lichen sclerosis or squamous cell hyperplasia?

Answer 5

Keratinizing SCC

Question 6

What is composed of loose fibromyxomatous stroma covered by mucus-secreting endocervical glands often accompanied by inflammation?

Causes what?

Answer 6

Endocervical polyps

Irregular vaginal spotting

Question 7

What is in Gardasil?

Answer 7

Vaccine for HPV 6, 11, 16, 18

Question 9

Small-cell neuroendocrine tumors of the cervix have what prognosis?

Answer 9

VERY poor

Question 10

Basaloid and warty carcinomas caused by what?

Answer 10

HPV 16

Question 12

What is the next step when a PAP smear is abnormal?

Answer 12

Colposcopic exam of cervix and vagina

Then biopsy if needed

Question 13

DES is associated with what rare cancer?

Answer 13

Clear Cell adenocarcinoma

Question 15

Blockage of mucosal glands in cervical area causes what?

Answer 15

Nabothian cyst

Question 17

Neuroendocrine cervical carcinoma has an appearance similar to what?

What is different?

Answer 17

Small cell carcinoma of the lung

(+) for high risk HPV

Question 19

HPV + what co-carcinogens cause cancer of the cervix?

Answer 19

Cigarettes
Microbial infections
Hormone changes
Diet deficiency

Question 21

What epithelium is the vagina?

Answer 21

SSNK

Question 23

Cervical Moderate Dysplasia is what CIN?

Severe?

Answer 23

CIN II

CIN III

Question 25

What benign entity produces pain and discomfort, and results from obstruction of a duct in females?

Answer 25

Bartholin Cyst

Question 27

Cervical carcinoma avg age?

What types?

Answer 27

45

SCC (80%)
Adenocarcinoma (15%)
Mixed/neuroendocrine (5%) –> worst prognosis

Question 28

Koilocytic atypia is from what?

Answer 28

HPV

Question 29

Cambium layer?

Answer 29

Sarcoma botyroides

Question 30

5yr survival for microinvasive cervical carcinoma?

Answer 30

100%

Question 31

Cervical Mild dysplasia is what CIN?

What squamous intraepithelial lesion classification?

Answer 31

CIN I

LSIL

Question 33

Lichen Sclerosis occurs in whom?

Described as what?

Increased risk of what?

Answer 33

Postmenopausal women

Leukoplakia that is paper thin w/T cell infiltrate

SCC

Question 34

What is upregulated and useful in diagnosing SIL in HPV (+) cases?

Answer 34

Ki-67

P16

Question 35

Ectocervix has what epithelium?

Answer 35

SSNK

Question 37

What has the same histology as intraductal papilloma of the breast and is a sharply-circumscribed nodule found on the labia majora which can ulcerate?

Answer 37

Papillary Hidradenoma

Question 39

What is is an intraepithelial proliferation of malignant cells w/pale cytoplasm w/MPS staining PAS (+)?

Answer 39

Extramammary Paget

Question 43

What occurs in infants and children < 5 y/o and can cause death by penetration into the peritoneal cavity or by obstructing the urinary tract?

Answer 43

Embryonal Rhabdomyosarcoma

Question 44

Tumors affecting the upper vagina spread to what LNs? Lower 2/3rds?

Answer 44

Regional iliac Inguinal

Question 46

What presents as a pruritic, red, crusted, maplike area usually on the labia majora? Means what?

Answer 46

Extramammary Paget Disease NOT necessarily cancer

Question 47

What may cause septation (double vagina) or vaginal adenosis?

Answer 47

DES

Question 51

What is common along the lateral wall derived from the Wolffian (mesonephric) duct in the proximal vagina?

Answer 51

Gartner duct cyst

Question 55

What is cytokeratin 7 (+)?

Answer 55

Extramammary Paget's

Question 57

Which vulvar intraepithelial neoplasia is a pre-malignant lesion? Has what morphology?

Answer 57

Differentiated Central keratin pearls