Female Genital Tract - Amy Flashcards

1
Q

Endocervix has what epithelium?

A

Single layer of columnar

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3
Q

What is and what causes squamous cell hyperplasia?

Histology?

Premalignant?

A

Small flat papule, due to chronic rubbing or scratching to relieve itching

Hyperkeratosis w/thickened epidermis w/some lymphocytes

NO

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4
Q

What causes a condylomata Acuminatum?

Viral change called what?

A

HPV 6 and 11

Koilocytic atypia

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5
Q

What may develop in older women due to long standing lichen sclerosis or squamous cell hyperplasia?

A

Keratinizing SCC

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6
Q

What is composed of loose fibromyxomatous stroma covered by mucus-secreting endocervical glands often accompanied by inflammation?

Causes what?

A

Endocervical polyps

Irregular vaginal spotting

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7
Q

What is in Gardasil?

A

Vaccine for HPV 6, 11, 16, 18

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9
Q

Small-cell neuroendocrine tumors of the cervix have what prognosis?

A

VERY poor

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10
Q

Basaloid and warty carcinomas caused by what?

A

HPV 16

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12
Q

What is the next step when a PAP smear is abnormal?

A

Colposcopic exam of cervix and vagina

Then biopsy if needed

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13
Q

DES is associated with what rare cancer?

A

Clear Cell adenocarcinoma

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15
Q

Blockage of mucosal glands in cervical area causes what?

A

Nabothian cyst

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17
Q

Neuroendocrine cervical carcinoma has an appearance similar to what?

What is different?

A

Small cell carcinoma of the lung

(+) for high risk HPV

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19
Q

HPV + what co-carcinogens cause cancer of the cervix?

A

Cigarettes
Microbial infections
Hormone changes
Diet deficiency

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21
Q

What epithelium is the vagina?

A

SSNK

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23
Q

Cervical Moderate Dysplasia is what CIN?

Severe?

A

CIN II

CIN III

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25
Q

What benign entity produces pain and discomfort, and results from obstruction of a duct in females?

A

Bartholin Cyst

27
Q

Cervical carcinoma avg age?

What types?

A

45

SCC (80%)
Adenocarcinoma (15%)
Mixed/neuroendocrine (5%) –> worst prognosis

28
Q

Koilocytic atypia is from what?

A

HPV

29
Q

Cambium layer?

A

Sarcoma botyroides

30
Q

5yr survival for microinvasive cervical carcinoma?

A

100%

31
Q

Cervical Mild dysplasia is what CIN?

What squamous intraepithelial lesion classification?

A

CIN I

LSIL

33
Q

Lichen Sclerosis occurs in whom?

Described as what?

Increased risk of what?

A

Postmenopausal women

Leukoplakia that is paper thin w/T cell infiltrate

SCC

34
Q

What is upregulated and useful in diagnosing SIL in HPV (+) cases?

A

Ki-67

P16

35
Q

Ectocervix has what epithelium?

A

SSNK

37
Q

What has the same histology as intraductal papilloma of the breast and is a sharply-circumscribed nodule found on the labia majora which can ulcerate?

A

Papillary Hidradenoma

39
Q

What is is an intraepithelial proliferation of malignant cells w/pale cytoplasm w/MPS staining PAS (+)?

A

Extramammary Paget

43
Q

What occurs in infants and children < 5 y/o and can cause death by penetration into the peritoneal cavity or by obstructing the urinary tract?

A

Embryonal Rhabdomyosarcoma

44
Q

Tumors affecting the upper vagina spread to what LNs?

Lower 2/3rds?

A

Regional iliac

Inguinal

46
Q

What presents as a pruritic, red, crusted, maplike area usually on the labia majora?

Means what?

A

Extramammary Paget Disease

NOT necessarily cancer

47
Q

What may cause septation (double vagina) or vaginal adenosis?

A

DES

51
Q

What is common along the lateral wall derived from the Wolffian (mesonephric) duct in the proximal vagina?

A

Gartner duct cyst

55
Q

What is cytokeratin 7 (+)?

A

Extramammary Paget’s

57
Q

Which vulvar intraepithelial neoplasia is a pre-malignant lesion?

Has what morphology?

A

Differentiated

Central keratin pearls