FBC abnormalities

Question 1

Pancytopenia: what is it

Answer 1

anaemia, thrombocytopenia, and leukopenia

Question 2

Pancytopenia: causes
1. Causes of […] marrow […] function
- […] and […] (the pancytopenia may be transient)
- Vitamin […] and […] deficiency.
- […] or lymphomas
- […], in which there is progressive marrow fibrosis
- […] […] (a plasma cell dyscrasia)
- […] infection in haemolytic disease (such as sickle cell anaemia)

2. […] causes of marrow failure - […] anaemia (autosomal recessive) and […] […] (X-linked).
3. Increased […]/[…] of blood cells peripherally –> liver disease e.g. cirrhosis, autoimmune hepatitis, hep B/C)
4. […]destruction of blood cells (iatrogenic e.g. sulphonamide or rifampicin)

Answer 2

1. Causes of decreased marrow haematopoetic function
   - chemotherapy and radiotherapy (the pancytopenia may be transient)
   - Vitamin B12 and folate deficiency.
   - leukaemias or lymphomas
   - Myelofibrosis, in which there is progressive marrow fibrosis
   - Multiple myeloma (a plasma cell dyscrasia)
   - Parvovirus infection in haemolytic disease (such as sickle cell anaemia)
2. Inherited causes of marrow failure - Fanconi’s anaemia (autosomal recessive) and dyskeratosis congenita (X-linked).
3. Increased destruction/sequestration of blood cells peripherally –> liver disease e.g. cirrhosis, autoimmune hepatitis, hep B/C)
4. Immune destruction of blood cells (iatrogenic e.g. sulphonamide or rifampicin)