FA Run #2 Flashcards
1
Q
Amino acids necessary for purine synthesis
A
GAG - glycine, aspartate, glutamine
2
Q
Mechanism of de novo purine synthesis
A
- Start with sugar (ribose-5-P) and phosphate (PRPP)
2. Add base
3
Q
Mechanism of de novo pyrimidine synthesis
A
- Make temporary base (orotic acid)
- Add sugar (ribose-5-p) and phosphate (PRPP)
- Modify base
4
Q
Mycophenolate and ribavirin inhibit ____
A
IMP DHGN
5
Q
Leflunomide inhibits ____
A
Dihydroorate DHGN
6
Q
6-MP and azathioprine inhibit __
A
De novo purine synthesis
7
Q
5-FU inhibits ___
A
Thymidylate synthase
8
Q
MTX, TMP, and pyrimethamine inhibit ___
A
DHFR
9
Q
Carbamoyl phosphate is involved in 2 pathways. . . which?
A
Urea cycle and de novo pyrimidine synthesis
