FA 2014: Hem Drugs Flashcards
LMWHs
Enoxaparin, dalteparin, fondaparinux
Mechanism of HIT
IgG against Heparin:PF4 –> thrombocytopenia
Treatment of HIT
Direct thrombin inhibitors (argatroban, bivalirudin, leupridin)
Direct factor Xa inhibitors
Apixaban, rivaroxaban
Direct thrombin inhibitors
Argatroban, bivalirudin, leupridin
Mechanism of heparin
Heparin –> antithrombin –> decreased IIa/Xa
Treatment for thrombolytic tox
Aminocaproic acid
Treatment for heparin tox
Protamine sulfate
ASA effect on clotting
Elevated bleeding time, no effect on PT/PTT
ASA toxicity
Gastric ulceration, tinnitus, interstitial nephritis, Reye syndrome
Resp alkalosis –> metabolic acidosis
ADP receptor inhibitors
Clopidogrel (Plavix), ticlopidine, prasugrel, ticagrelor
Neutropenia in patient taking stroke prophylaxis
Ticlopidine effect
Mechanism of ADP-R inhibitors
Inhibit platelet aggregation, fibrinogen binding by preventing GpIIb/IIIa binding
PDE-III inhibitors
Cilostazol, dipyridamole
Mechanism of PDE-III inhibitors
Raise cAMP in platelets –| aggregation, vasodilators
Use of PDE-III inhibitors
Intermittent claudication, TIA/stroke prevention, angina prophylaxis
GPIIb/IIIa inhibitors
Abciximab, eptifibatide, tirofiban
Use of GPIIb/IIIa inhibitors
Unstable angina, PCI angioplasty
Toxicity of GPIIb/IIIa inhibitors
Thrombocytopenia, bleeding
