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1 STEP Uworld biochemistry > FA piruvatas (complex) 12/22 > Flashcards

FA piruvatas (complex) 12/22 Flashcards

1
Q

PDH (pyruvate dehydrogenase complex) located where?

A

in mitochondria

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2
Q

what links PDH?

A

Glycolysis and TCA cycle

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3
Q

is regulation of PDH is same in fed and fasting states?

A

no. In fed state - active; in fasting - inactive

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4
Q

what is net reaction?

A

Pyruvate+NAD+CoA –> acetylCoa+CO2+NADH

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5
Q

What 5 cofactors for PDH?

A 
Thiamine phosphate (B1)
FAD (B2)
NAD (B3)
CoA (B5)
Lipoic acid
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6
Q

What activates PDH? 3

A

incr. NAD/NADH ratio (cia sitas dalykas inc. in alcohol)
incr. ADP
inc. Ca2+

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7
Q

What inhibits PDH? 3

A

ATP;
AcetylCoA
NADH

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8
Q

incr. NAD/NADH ratio on PDH?

A

activates

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9
Q

incr. ADP on PDH?

A

activates

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10
Q

inc. Ca2+ on PDH?

A

activates

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11
Q

ATP on PDH?

A

Inhibits

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12
Q

AcetylCoA on PDH?

A

Inhibits

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13
Q

NADH on PDH?

A

Inhibits

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14
Q

what does arsenic?

A

inhibits lipoic acid

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15
Q

PDH deficiency. Age?

A

infancy

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16
Q

PDH deficiency. Manifestation?

A

neurologic defect, lactic acidosis, inc. serum alanine

17
Q

PDH deficiency. mechanism?

A

X-linked; causes buildup of pyruvate that gets shunted to lactate (via LDH) and alanine (via ALT).

18
Q

Alanine aminotransferase. What vitamin?

A

B6

19
Q

Alanine function?

A

alanine carries amino groups to the liver from muscle (cahill cycle)

20
Q

Pyruvate carboxylase, what vitamin?

A

biotin (B7)

21
Q

OAA functions?2

A

can replenish TCA cycle or be used in gluconeogenesis

22
Q

Pyruvate dehydrogenase, what vitamins?

A

B1, 2, 3, 5, lipoic acid

23
Q

Pyruvate dehydrogenase, function?

A

transition from glycolysis to TCA cycle

24
Q

Lactic acid dehydrogenase, what vitamin?

A

B3

25
Q

reaction of Lactic acid dehydrogenase, what function?

A

end of anaerobic glycolysis.

26
Q

anaerobic glycolysis where in body?

A

RBC, WBC, kidney medulla, lens, testes, cornea

1 STEP Uworld biochemistry (13 decks)

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