FA hexokinase vs glucokinase; el. acceptors 12/22

Question 1

location of glucokinase?

Answer 1

LIVER, beta cells of pancreas

Question 2

location of hexokinase?

Answer 2

most tissues, except liver and pancreatic beta-cells

Question 3

Km of glucokinase?

Answer 3

Higher (decr. affinity)

Question 4

Km of hexokinase?

Answer 4

lower (incr. affinity)

Question 5

Vmax of glucokinase?

Answer 5

Higher (incr capacity)

Question 6

Vmax of hexokinase?

Answer 6

lower (decr capacity)

Question 7

Glucokinase induced by insulin?

Answer 7

Yes

Question 8

Hexokinase induced by insulin?

Answer 8

No

Question 9

Feedback-inhibited by glucose-6-P? glucokinase?

Answer 9

No

Question 10

Feedback-inhibited by glucose-6-P? Hexokinase?

Answer 10

Yes

Question 11

What are universal electron acceptors?

Answer 11

Nicotinamides and flavin nucleotides

Question 12

what are Nicotinamides?

Answer 12

NAD+ and NADP+

Question 13

origin of nicotinamides?

Answer 13

from vitamin B3

Question 14

what are flavin nucleotides?

Answer 14

FAD

Question 15

origin of flavin nucleotides?

Answer 15

vitamin B2

Question 16

NAD+ is generally used in what type of reactions?

Answer 16

CATABOLIC processes to carry reducing equivalents away as NADH.

Question 17

NADPH is generally used in what type of reactions?

Answer 17

ANABOLIC precesses (eg steroid and fatty acids synthesis), as a supply of reducing equivalents.

Question 18

what acceptors participates in catabolic rections?

Answer 18

NAD+ (carry away)

Question 19

what molecule participates in anabolic rections?

Answer 19

NADPH (supply)

Question 20

NADPH is a product of what reaction?

Answer 20

HMP shunt

Question 21

NADPH is used in what 4 processes?

Answer 21

Anabolic processes;
Respiratory burst;
CYP450 system;
Glutathione reductase

Question 22

Anabolic processes, what molecule is used?

Answer 22

NADPH

Question 23

Respiratory burst, what molecule is used?

Answer 23

NADPH

Question 24

CYP450 system, what molecule is used?

Answer 24

NADPH

Question 25

Glutathione reductase, what molecule is used?

Answer 25

NADPH

Question 26

When glucokinase takes action?

Answer 26

at high glucose concentrations, glucokinase helps to store glucose in liver.

Question 27

When hexokinase takes action?

Answer 27

hexokinase sequesters glucose in tissues, where it is used even when glucose concentrations are low.