FA hexokinase vs glucokinase; el. acceptors 12/22 Flashcards
location of glucokinase?
LIVER, beta cells of pancreas
location of hexokinase?
most tissues, except liver and pancreatic beta-cells
Km of glucokinase?
Higher (decr. affinity)
Km of hexokinase?
lower (incr. affinity)
Vmax of glucokinase?
Higher (incr capacity)
Vmax of hexokinase?
lower (decr capacity)
Glucokinase induced by insulin?
Yes
Hexokinase induced by insulin?
No
Feedback-inhibited by glucose-6-P? glucokinase?
No
Feedback-inhibited by glucose-6-P? Hexokinase?
Yes
What are universal electron acceptors?
Nicotinamides and flavin nucleotides
what are Nicotinamides?
NAD+ and NADP+
origin of nicotinamides?
from vitamin B3
what are flavin nucleotides?
FAD
origin of flavin nucleotides?
vitamin B2
NAD+ is generally used in what type of reactions?
CATABOLIC processes to carry reducing equivalents away as NADH.
NADPH is generally used in what type of reactions?
ANABOLIC precesses (eg steroid and fatty acids synthesis), as a supply of reducing equivalents.
what acceptors participates in catabolic rections?
NAD+ (carry away)
what molecule participates in anabolic rections?
NADPH (supply)
NADPH is a product of what reaction?
HMP shunt
NADPH is used in what 4 processes?
Anabolic processes;
Respiratory burst;
CYP450 system;
Glutathione reductase
Anabolic processes, what molecule is used?
NADPH
Respiratory burst, what molecule is used?
NADPH
CYP450 system, what molecule is used?
NADPH
