FA Pathology Disease Conditions Associated with Neoplasms

Question 1

Down syndrome

Answer 1

ALL (“we ALL fall Down”), AML

Question 2

Xeroderma pigmentosum, albinism

Answer 2

Melanoma, basal cell carcinoma, and especially

squamous cell carcinomas of skin

Question 3

Chronic atrophic gastritis, pernicious anemia,

postsurgical gastric remnants

Answer 3

Gastric adenocarcinoma

Question 4

Tuberous sclerosis (facial angiofibroma,
seizures, mental retardation)

Answer 4

Giant cell astrocytoma, renal angiomyolipoma,

and cardiac rhabdomyoma

Question 5

Actinic keratosis

Answer 5

Squamous cell carcinoma of skin

Question 6

Barrett’s esophagus (chronic GI reflux)

Answer 6

Esophageal adenocarcinoma

Question 7

Plummer-Vinson syndrome (decrease iron)

Answer 7

Squamous cell carcinoma of esophagus

Question 8

Cirrhosis (alcoholic, hepatitis B or C)

Answer 8

Hepatocellular carcinoma

Question 9

Ulcerative colitis

Answer 9

Colonic adenocarcinoma

Question 10

Paget’s disease of bone

Answer 10

Secondary osteosarcoma and fibrosarcoma

Question 11

Immunodeficiency states

Answer 11

Malignant lymphomas

Question 12

AIDS

Answer 12

Aggressive malignant lymphomas (nonI-

Iodgkin’s) and Kaposi’s sarcoma

Question 13

Autoimmune diseases (e.g., Hashimoto's
thyroiditis, myasthenia gravis)

Answer 13

Lymphoma

Question 14

Acanthosis n igricans (hyperpigmentation and

epidermal thickening)

Answer 14

Visceral malignancy (stomach, lung, uterus)

Question 15

Dysplastic nevus

Answer 15

Malignant melanoma

Question 16

Radiation exposure

Answer 16

Leukemia, sarcoma, papillary thyroid cancer,

and breast cancer.