FA Path Section Flashcards
P-glycoprotein seen in what cancer?
Adrenocortical carcinoma
Polycythemia can indicated what neoplastic cancers?
RCC, HCC
Hemangioblastoma
Pheo
Leiomyoma
50% of brain tumors are from metastasis, what are the MC sites?
Tumors located where in brain?
Lung > breast > melanoma > colon
Gray-white matter junction
1-3 Cancer incidence in women
Breast, lung, colon
Lung, breast, colon
What substances cause angiocarcinoma?
VAT
Vinyl chloride
Arsenic
Thorotrast
What tumors in MEN1?
What ch. and gene?
ALL the Pās
Pituitary adenoma
Pancreatic endocrine tumor (ZE, insulinoma, VIPoma, glucagonma)
Parathyroid adenoma
11, Menin
What carcinogen is the #2 cause of lung cancer after smoke?
Radon
What cancers route hematogenously?
Four Carcinomas Route Hematogenously Follicular thyroid cancer Choriocarcinoma RCC HCC
1-3 Cancer incidence in men
Prostate, lung, colon
Lung, prostate, colon
CA-15-3 or CA27-29 marker for what?
Breast cancer
Age-related (senile) amyloid due to what?
Predominantly where?
Transthyretin
Cardiac ventricles
What tumors in MEN2A?
What gene mutation?
Parathyroid herplasia
Medullary thyroid cancer (C cells)
Pheochromacytoma
RET
CA19-9 marker for what?
Pancreatic adenocarcinoma
Opsoclonus-myoclonus ataxia syndrome present w/what tumor in children?
Adults?
Neuroblastoma
Small cell lung cancer
AFP seen in what cancers?
HCC, hepatoblastoma
Yolk sac
Mixed germ cell tumor
What do you need to check for before starting anti-TNF therapy?
Why?
Latent Tb
TNF-a maintains granulomas, killing them will cause disseminated Tb infection
CEA major associations?
Colorectal cancer
Pancreatic cancer
High levels of AFP seen in what?
Low?
NTD and abdominal wall defect
Down syndrome
What causes cholangiocarcinoma?
Liver fluke (clonorchis sinesis)
What is the only blastic form of metastatic cancer to bone?
Prostate cancer
CA125 marker for what?
Ovarian cancer
What tumors in MEN2B?
What gene mutation?
Medullary thyroid cancer
Pheochromacytoma
Mucosal neuromas
Marfanoid habitus
RET
Fibrils composed of B2-microglobulin is amyloid seen in what patients?
May present how?
Dialysis, ESRD pts
Carpal Tunnel syndrome
Psammoma bodies found in what tumors?
PSaMM Papillary carcinoma of thyroid Serous papillary cystadenocarcinoma of ovary Meningioma Mesothelioma
Calcitonin deposition in tumor cells seen where?
Medullary carcinoma of the thyroid
The heritable form of amyloid is due to what?
Transthyretin gene mutation
AL amyloid is due to what?
Occurs in what?
Affects what organs?
Ig Light chains
Any plasma cell disorder, Multiple myeloma
Many - renal, cardiac, GI, neuro, etc
Amyloid deposition to ventricular endomyocardium causes what?
Restrictive cardiomyopathy
Alzheimer amyloid is described how?
B-amyloid protein cleaved from APP
What is CD31?
For what stage?
PECAM-1
Diapedesis then Migration
AA amyloid seen in what?
Fibrils composed of what?
What class?
Chronic inflammatory conditions ā> R.A., IBD, spondyloarthropathy, familial Mediterranean fever
Amyloid A
Secondary
What kind of amyloid is seen in T2DM?
Due to what?
Islet amyloid polypeptide (IAPP)
Deposition of amlyin in pancreatic islets
What neurons in brain are most susceptible to hypoxia-ischemia?
Purkinje cells of cerebellum and pyramidal cells of the hippocampus and neocortex (zones 3, 5, 6)
2?
M.G. MC pathology seen with it?
B cell hyperplasia
thymoma
