FA Path Section

Question 1

P-glycoprotein seen in what cancer?

Answer 1

Adrenocortical carcinoma

Question 3

Polycythemia can indicated what neoplastic cancers?

Answer 3

RCC, HCC
Hemangioblastoma
Pheo
Leiomyoma

Question 4

50% of brain tumors are from metastasis, what are the MC sites?

Tumors located where in brain?

Answer 4

Lung > breast > melanoma > colon

Gray-white matter junction

Question 6

1-3 Cancer incidence in women

Answer 6

Breast, lung, colon

Lung, breast, colon

Question 7

What substances cause angiocarcinoma?

Answer 7

VAT
Vinyl chloride
Arsenic
Thorotrast

Question 10

What tumors in MEN1?

What ch. and gene?

Answer 10

ALL the P’s
Pituitary adenoma
Pancreatic endocrine tumor (ZE, insulinoma, VIPoma, glucagonma)
Parathyroid adenoma

11, Menin

Question 11

What carcinogen is the #2 cause of lung cancer after smoke?

Answer 11

Radon

Question 12

What cancers route hematogenously?

Answer 12

Four Carcinomas Route Hematogenously
Follicular thyroid cancer
Choriocarcinoma
RCC
HCC

Question 14

1-3 Cancer incidence in men

Answer 14

Prostate, lung, colon

Lung, prostate, colon

Question 15

CA-15-3 or CA27-29 marker for what?

Answer 15

Breast cancer

Question 18

Age-related (senile) amyloid due to what?

Predominantly where?

Answer 18

Transthyretin

Cardiac ventricles

Question 19

What tumors in MEN2A?

What gene mutation?

Answer 19

Parathyroid herplasia
Medullary thyroid cancer (C cells)
Pheochromacytoma

RET

Question 22

CA19-9 marker for what?

Answer 22

Pancreatic adenocarcinoma

Question 23

Opsoclonus-myoclonus ataxia syndrome present w/what tumor in children?

Adults?

Answer 23

Neuroblastoma

Small cell lung cancer

Question 24

AFP seen in what cancers?

Answer 24

HCC, hepatoblastoma
Yolk sac
Mixed germ cell tumor

Question 25

What do you need to check for before starting anti-TNF therapy?

Why?

Answer 25

Latent Tb

TNF-a maintains granulomas, killing them will cause disseminated Tb infection

Question 27

CEA major associations?

Answer 27

Colorectal cancer

Pancreatic cancer

Question 28

High levels of AFP seen in what?

Low?

Answer 28

NTD and abdominal wall defect

Down syndrome

Question 30

What causes cholangiocarcinoma?

Answer 30

Liver fluke (clonorchis sinesis)

Question 31

What is the only blastic form of metastatic cancer to bone?

Answer 31

Prostate cancer

Question 32

CA125 marker for what?

Answer 32

Ovarian cancer

Question 35

What tumors in MEN2B?

What gene mutation?

Answer 35

Medullary thyroid cancer
Pheochromacytoma
Mucosal neuromas
Marfanoid habitus

RET

Question 36

Fibrils composed of B2-microglobulin is amyloid seen in what patients?

May present how?

Answer 36

Dialysis, ESRD pts

Carpal Tunnel syndrome

Question 37

Psammoma bodies found in what tumors?

Answer 37

PSaMM
Papillary carcinoma of thyroid
Serous papillary cystadenocarcinoma of ovary
Meningioma 
Mesothelioma

Question 38

Calcitonin deposition in tumor cells seen where?

Answer 38

Medullary carcinoma of the thyroid

Question 39

The heritable form of amyloid is due to what?

Answer 39

Transthyretin gene mutation

Question 48

AL amyloid is due to what? Occurs in what? Affects what organs?

Answer 48

Ig Light chains Any plasma cell disorder, Multiple myeloma Many - renal, cardiac, GI, neuro, etc

Question 50

Amyloid deposition to ventricular endomyocardium causes what?

Answer 50

Restrictive cardiomyopathy

Question 51

Alzheimer amyloid is described how?

Answer 51

B-amyloid protein cleaved from APP

Question 55

What is CD31? For what stage?

Answer 55

PECAM-1 Diapedesis then Migration

Question 56

AA amyloid seen in what? Fibrils composed of what? What class?

Answer 56

Chronic inflammatory conditions --> R.A., IBD, spondyloarthropathy, familial Mediterranean fever Amyloid A Secondary

Question 57

What kind of amyloid is seen in T2DM? Due to what?

Answer 57

Islet amyloid polypeptide (IAPP) Deposition of amlyin in pancreatic islets

Question 64

What neurons in brain are most susceptible to hypoxia-ischemia?

Answer 64

Purkinje cells of cerebellum and pyramidal cells of the hippocampus and neocortex (zones 3, 5, 6)

Question 65

M.G. MC pathology seen with it? #2?

Answer 65

B cell hyperplasia thymoma