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Board Prep > Cancer Drugs > Flashcards

Cancer Drugs Flashcards

1
Q

When giving Azathioprine and 6-MP what do you have to be careful with?

What drugs to avoid with it?

A

XO inhibitors bc they will greatly increase its dose

Allopurinol, Febuxostat

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2
Q

What drug used to treat stage 4 colorectal cancer (KRAS) and SEs include rash w/elevated LFTS?

MOA?

A

Cetuximab

Mab against EGFR

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5
Q

What drugs are in ABVD?

A

Adriamycin (doxorubicin)
Bleomycin
Vincristine
Dacarbazine

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6
Q

Cisplatin MOA?

SE?

A

Cross-links DNA

Nephrotoxic, ototoxic, peripheral neuropathy

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7
Q

MOA of trastuzumab (herceptin)?

SE?

A

Mab against HER2 (c-erbB2), Tyr Kinase, tx for breast cancer

Heart damage

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8
Q

What drug is used to treat RCC and colorectal cancer?

MOA?

A

Bevacizumab

Mab against VEGF

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9
Q

High doses of what drug requires rescue with leucovorin?

A

Methotrexate

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12
Q

What drugs treat multiple myeloma and mantle cell lymphoma w/side effects of peripheral neuropathy and reactivation of herpes zoster?

MOA?

Arrest cell cycle when?

A

Bortezomib, carfilzomib

26S proteosome inhibitors

G2-M

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14
Q

What drug inhibits microtubule polymerization?

SE?

A

Vinca alkaloids - vincristine binds B-tubular

peripheral neuropathy, neurotoxicity

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15
Q

What drug regimen treatment for NHL?

A 
CHOP
Cyclophosphamide 
Hydroxy-danurubicin (Doxorubicin)
Oncovorin - Vincristine
Prednisone
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16
Q

Busulfan treats what?

SE?

A

CML

Myelosuppression

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19
Q

Etoposide and teniposide have what MOA?

Tx what?

Act in what cell cycle phase?

SE?

A

Inhibit topo II –> double strand DNA breaks

Testicular, small cell lung

G2 and S

Myelosuppression, alopecia

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20
Q

MOA of Rasburicase?

tx for what?

A

Catalyzes uric acid —> allantoin

Tumor lysis syndrome

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21
Q

MOA of bleomycin?

Cell cycle?

A

induces free radicals, breaks in DNA

G2

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23
Q

Hydroxyurea MOA?

Acts in what cell cycle phase?

Tx what?

A

Inhibits ribonucleotide reductase, Dec DNA synthesis

S phase

CML, PV, sickle cell

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24
Q

What drug inhibits BRAF oncogene for treatment of melanoma?

What BRAF mutation specifically?

A

Vemurafenib

V600E

25
Q

How do alkylating agents work (MOA)?

Name some drugs (4)

A

Cross-link DNA

Busulfan
Cyclophosphamide, ifosfamide
Nitrosoureas

26
Q

MOA for cytarabine?

Tx what?

SE?

A

Inhibits DNA polymerase, S phase

AML

Pancytopenia

29
Q

MOA of 5-FU?

What is a prodrug with similar activity?

SE?

A

Inhibits thymidylate synthase

Capecitabine

Myelosuppression, HAND-FOOT syndrome

30
Q

Which SERM has no risk for endometrial carcinoma?

Which SERM is mainly used for breast cancer treatment?

A

Raloxifene

Tamoxifen

31
Q

What drug competitively inhibits DHF reductase and is a folic acid analog?

Must give what when used in high doses?

Cell cycle?

A

Methotrexate

Leucovorin

S phase

32
Q

MOA of doxorubicin?

A

Generates free radicals

Intercalated DNA –> breaks in DNA

33
Q

What can imatinib treat?

With what gene mutations?

A

CML, GIST

Tyr kinase, c-kit

36
Q

What drugs hyperstabilize microtubules?

Tx what?

SE?

A

Paclitaxel

Ovarian/breast CA

Myelosuppression

39
Q

Nitrosoureas treat what?

MOA?

What is special about them?

A

Brain tumors - GBM

Cross-link DNA

Cross BBB into CNS

41
Q

Irinotecan, topotecan MOA?

Act in what cell cycle phase?

Tx what?

A

Inhibit topo I –> single strand DNA breaks

S phase and G2

Colon (Irino) and small cell lung (topot)

45
Q

Cyclophosphamide (ifosfamide) is considered what?

Acts how?

Major SE?

A

Nitrogen mustard

Cross-links DNA at guanine N-7

Hemorrhagic cystitis, give MESNA

46
Q

Which 2 drugs are purine analogs that decrease purine syntheses and are activated by HGPRT?

What cell cycle phase?

SEs?

A

Azathioprine, 6-MP

S phase

Myelosuppression, GI, liver

49
Q

SE of methotrexate?

A

Myelosuppression - give leucovorin

Hepatotoxicity

50
Q

What are the 2 cancer regimens to treat HL?

A

BEACOPP

ABVD

53
Q

What drug treats topical BCC?

A

5-FU

55
Q

What drugs are in BEACOPP?

A

Bleomycin, etoposide, doxorubicin (Adriamycin), Cyclophosphamide, Vincristine (Oncovin), Procarbazine, Prednisone

Board Prep (19 decks)

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