Extras: Summary Sheet Drugs

Question 1

what substance can be seen on mesothelioma stain?

Answer 1

calretinin

Question 2

five parenteral anticoagulants and five oral anticoagulants

Answer 2

1. parenteral: heparin, enoxaparin, fondaparinux, bivalirudin, argatroban
2. oral: warfarin, rivaroxaban, apixaban, endoxaban, dabigatran

Question 3

group of meds where jaw pain is a side effect

Answer 3

prostacyclin analogs

Question 4

only prostacyclin analog given via continuous IV infusion

Answer 4

epoprostenol

Question 5

MOA of bosentan vs ambrisentan

Answer 5

1. bosentan: binds ETa and ETb

2. ambrisentan: binds ETa only

Question 6

two major AEs for endothelin receptor antagonists

Answer 6

1. teratogenesis

2. hepatotox

Question 7

only SABA available by subq injection

Answer 7

terbutaline

Question 8

two major AEs for SABAS

Answer 8

1. CV effects

2. paradoxical bronchospasms

Question 9

why atropine dose must be restricted

Answer 9

detrimental tachycardia

Question 10

three groups of pts that should not take methylxanthines

Answer 10

1. PUD
2. seizures
3. arrythmias

Question 11

four AEs of ICS

Answer 11

1. thrush
2. PNA
3. hoarse voice
4. osteoporosis

Question 12

which two ICS can cause adrenal insufficiency when switching from OCS to ICS

Answer 12

1. beclomethasone

2. triamcinolone

Question 13

which ICS has a lower risk of oral thrush?

Answer 13

ciclesonide

Question 14

which two ICS are contraindicated in pts with milk allergies?

Answer 14

budesonide, mometasone

Question 15

biggest AE in OCS

Answer 15

HPA axis suppression - look for Cushings or hyperglycemia

Question 16

MOA for Zafirlukast vs Montelukast

Answer 16

1. Montelukast: inhibits CysLT1 receptor so LTD4 cant bind

2. Zafirlukast: inhibits 5-lipoxyngenase -> less LT B4, C4, D4, E4

Question 17

AE of zafirlukast

Answer 17

hepatotoxicity

Question 18

what test must pts take before taking omalizumab?

Answer 18

positive test for perennial aeroallergens

Question 19

major AE for Omalizumab

Answer 19

anaphylaxis - must be given in a healthcare setting

Question 20

five drugs for ILD

Answer 20

1. prednisone
2. mycophenylate
3. methotrexate
4. azathioprine
5. nintedanib

Question 21

ILD drugs are immunosuppresants besides which one, and what is the MOA?

Answer 21

nintedanib - kinase inhibitor

Question 22

which two ILD drugs are also used for prophylaxis for organ transplant rejection?

Answer 22

mycophenolate, azathioprine

Question 23

which ILD drugs have fetal toxicity

Answer 23

all but prednisone

Question 24

what drugs do mycophenolate, methotrexate, and nintedanib interact with?

Answer 24

1. mycophenylate: GERD drugs
2. methotrexate: NSAIDS, Abs, theophylline
3. nintedanib: CYP3A4, P-gp

Question 25

four major organ systems that methotrexate is toxic to

Answer 25

BM, liver, lungs, kidney