27: Drugs for PE, PAH

Question 1

acute vs chronic PE

Answer 1

1. acute: central within lumen, upstream distension of involved vessel
2. chronic: eccentric with 50%+ occlusion, evidence of recanalization, arterial web formation around the clot

Question 2

PAH definition

Answer 2

sustained mean pulmonary arterial pressure (mPAP) >20 mmHg at rest

Question 3

normal mPAP

Answer 3

14 +/- 3 mmHg

Question 4

three treatments that do not work on PAH

Answer 4

anticoagulants, diuretics, O2 therapy

Question 5

endothelin in pts with PAH

Answer 5

endothelin is elevated - directly related to dz severity and prognosis