Extras: PNS & Skeletal Muscle Flashcards
what NMJ condition tends to have thymic hyperplasia too?
myasthenia gravis
treatment for MG and LEMS
AchE inhibitors
two Ab types in seronegative MG
MUSK, LRP4
key presenting features of LEMS
dry mouth
botulinum MOA vs curare
- botulinum: blocks Ach release
2. curare: blocks AchR
histo of dermatomyositis
perifascicular atrophy
Abs in dermatomyositis
anti-Jo1, anti-Mi2
Abs in Immune-Mediated Necrotizing Myopathy
HMG-CoA reductase As
tx of inclusion body myositis
respond poorly to steroids
presentation of inclusion body myositis
weakness of hands + quads
DMD gene
Xp21
protein mutated in Limb-Girdle MD
sarcoglycan
Emery-Dreifuss triad
- humeroperoneal weakness
- cardiomyopathy
- contractures
SMA gene is on what chromosome
Chr 5
Barth syndrome
mitochondrial dz -> cardioskeletal myopathy
CSF in Guillain Barre
increaed protein
Abs in guillain Barre
anti-myelin Ab
MC acquired inflammatory peripheral neuropathy
CIDP
sural nerve Bx for CIDP
onion bulbs
two conditions that cause mononeuritis multiplex
- Vasculitis
2. HIV
MC viral infection of the PNS
varicella zoster
sx of Charcot Marie Tooth
atrophy, sensory loss, difficulty walking, arreflexia + pes cavus and hammer toes
type of neuropathy seen with thyroid issues
mononeuropathy
Parsonage-Turner Syndrome
autoimmune, post-infection severe shoulder pain -> weakness and atrophy for 6-18 months
pronator syndrome involves what nerve?
median
reflex associated with C7
Triceps
which is UMN and which is LMN: SMA and PLS
- SMA: LMN
2. PLS: UMN
UMN sx vs LMN sx
- UMN: spasticity, increased DTRs, Babinski sign
2. LMN: atrophy, fasciculations
