Extras: Bone, Joint, ST Flashcards
type 1 vs type 2 OI
type I normal lifespan, type II most die in utero
gene associated with osteoporosis
LRP5
cause of rickets and osteomalacia
vitamin D deficiency
what has brown tumors?
hyperparathyroidism
gene mutation in Paget’s
SQSTM1
two drugs to tx Paget disease
bisphosphonates, calcitonin
two main causes of AVN
fracture, corticosteroids
sequestrum and involucrum in osteomyelitis
sequestrum: dead bone after a subperiosteal abscess
involucrum: shel of living tissue around sequestrum
where does bacterial arthritis affect neonates?
epiphyseal plate
labs in juvenile idiopathic arthritis
ANA
MC ST tumor in adults
lipoma
two mutations in alveolar rhabdomyosarcoma
FOX, PAX3
common locations for rhabdomyosarcoma in kids
sinuses, head, neck, GU tract (vagina)
sarcoma botryoides
grape-like mass in embryonal rhabdomyosarcoma
where does leiomyosarcoma like to metz to?
lungs
what joints are involved in enteropathic arthritis
large joints of LEs + small joints of UEs + axial skeleton
osteochondroma
bony stalk capped by cartilage, with continuous medullary cavity with bone of origin
major location for chondromas vs chondrosarcomas
chondroma: hands & feet
chondrosarcoma: axial skeleton (ribs, shoulders, pelvis)
two mutations seen in chondrosarcoma
EXT, IDH1&2
what chr is gene EWSR on?
chr 22
soap bubble lesions seen with?
ABC: aneurysmal bone cyst
chr associated with ABC
chr17p13
two syndromes associated with fibrous dysplasia
McCune Albright, Mazabraud
