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2: NMSP Exam 2 > Extras: Bone, Joint, ST > Flashcards

Extras: Bone, Joint, ST Flashcards

1
Q

type 1 vs type 2 OI

A

type I normal lifespan, type II most die in utero

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2
Q

gene associated with osteoporosis

A

LRP5

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3
Q

cause of rickets and osteomalacia

A

vitamin D deficiency

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4
Q

what has brown tumors?

A

hyperparathyroidism

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5
Q

gene mutation in Paget’s

A

SQSTM1

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6
Q

two drugs to tx Paget disease

A

bisphosphonates, calcitonin

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7
Q

two main causes of AVN

A

fracture, corticosteroids

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8
Q

sequestrum and involucrum in osteomyelitis

A

sequestrum: dead bone after a subperiosteal abscess
involucrum: shel of living tissue around sequestrum

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9
Q

where does bacterial arthritis affect neonates?

A

epiphyseal plate

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10
Q

labs in juvenile idiopathic arthritis

A

ANA

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11
Q

MC ST tumor in adults

A

lipoma

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12
Q

two mutations in alveolar rhabdomyosarcoma

A

FOX, PAX3

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13
Q

common locations for rhabdomyosarcoma in kids

A

sinuses, head, neck, GU tract (vagina)

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14
Q

sarcoma botryoides

A

grape-like mass in embryonal rhabdomyosarcoma

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15
Q

where does leiomyosarcoma like to metz to?

A

lungs

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16
Q

what joints are involved in enteropathic arthritis

A

large joints of LEs + small joints of UEs + axial skeleton

17
Q

osteochondroma

A

bony stalk capped by cartilage, with continuous medullary cavity with bone of origin

18
Q

major location for chondromas vs chondrosarcomas

A

chondroma: hands & feet
chondrosarcoma: axial skeleton (ribs, shoulders, pelvis)

19
Q

two mutations seen in chondrosarcoma

A

EXT, IDH1&2

20
Q

what chr is gene EWSR on?

A

chr 22

21
Q

soap bubble lesions seen with?

A

ABC: aneurysmal bone cyst

22
Q

chr associated with ABC

A

chr17p13

23
Q

two syndromes associated with fibrous dysplasia

A

McCune Albright, Mazabraud

2: NMSP Exam 2 (18 decks)

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